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n. Biology
Reversion of a specialized cell or tissue to an unspecialized form. Dedifferentiation may occur before the regeneration of appendages in plants and certain animals and in the development of some cancers.

de′dif·fer·en′ti·ate′ v.


vb (intr)
to undergo the process of dedifferentiation
ThesaurusAntonymsRelated WordsSynonymsLegend:
Verb1.dedifferentiate - lose specialization in form or function
develop - grow, progress, unfold, or evolve through a process of evolution, natural growth, differentiation, or a conducive environment; "A flower developed on the branch"; "The country developed into a mighty superpower"; "The embryo develops into a fetus"; "This situation has developed over a long time"
differentiate - become different during development; "cells differentiate"
References in periodicals archive ?
Tropomysin 4 expression is enhanced in dedifferentiating smooth muscle cells in vitro and during atherogenesis.
The dedifferentiating mesothelium undergoes drastic simplification in its architecture, with both peritoneal and myoepithelial cells forming a simple epithelial layer of irregularly shaped cells (Fig.
In the shoots treated with IBA short radial rows of three-four successive dedifferentiating cells were observed in these zones (Fig.