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n. Biology
Reversion of a specialized cell or tissue to an unspecialized form. Dedifferentiation may occur before the regeneration of appendages in plants and certain animals and in the development of some cancers.

de′dif·fer·en′ti·ate′ v.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


vb (intr)
to undergo the process of dedifferentiation
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
ThesaurusAntonymsRelated WordsSynonymsLegend:
Verb1.dedifferentiate - lose specialization in form or function
develop - grow, progress, unfold, or evolve through a process of evolution, natural growth, differentiation, or a conducive environment; "A flower developed on the branch"; "The country developed into a mighty superpower"; "The embryo develops into a fetus"; "This situation has developed over a long time"
differentiate - become different during development; "cells differentiate"
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References in periodicals archive ?
An earlier study introduced fluorescent dextran-labeled myotubes into a regenerating limb stump and found the dye in the regenerated muscles and, in limited cases, the cartilage [28], suggesting the possibility that myofibers were capable of dedifferentiating into stem/progenitor cells and contributed to tissue regeneration.
The cellular morphology of dedifferentiating adipocytes is illustrated in Figure 1.
There have been cases of epithelial-myoepithelial carcinoma dedifferentiating into a high-grade carcinoma (HGC) with a proliferation index of 67.1% in the HGC and 11.5% in the epithelial-myoepithelial portion [9].
Tropomysin 4 expression is enhanced in dedifferentiating smooth muscle cells in vitro and during atherogenesis.
The dedifferentiating mesothelium undergoes drastic simplification in its architecture, with both peritoneal and myoepithelial cells forming a simple epithelial layer of irregularly shaped cells (Fig.