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n. Biology
Reversion of a specialized cell or tissue to an unspecialized form. Dedifferentiation may occur before the regeneration of appendages in plants and certain animals and in the development of some cancers.

de′dif·fer·en′ti·ate′ v.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Biology) the reversion of the cells of differentiated tissue to a less specialized form
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(diˌdɪf əˌrɛn ʃiˈeɪ ʃən)

n. Biol.
the loss of specialized form or condition previously acquired during development.
de`dif•fer•en′ti•ate`, v.i. -at•ed, -at•ing.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.dedifferentiation - the loss of specialization in form or function
adaption, adaptation, adjustment - the process of adapting to something (such as environmental conditions)
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
In patients on calcineurin inhibitors, the risk of keratinocyte carcinomas appears to be related to a direct effect of these agents on keratinocyte dedifferentiation. Belatacept is not believed to have any direct effects on keratinocytes, according to Mr.
Diffusion-weighted MR imaging: diagnosing atypical or malignant meningiomas and detecting tumor dedifferentiation. AJNR.
(24) Some tumors reveal features of dedifferentiation, such as prominent nucleoli, sarcomatoid change, or coagulative necrosis.
CSC is tailored with unlimited self-renewal; slow dividing capacity and is envisioned to originate either by several genetic and epigenetic alterations or precancerous phenotypic transformation in a normal, tissue-specific stem cell or by dedifferentiation of mature tumour cells.
They identified a similar K-RAS mutation in anaplastic carcinoma and previously resected mucinous tumor, and they suggested that it may show dedifferentiation rather than a collision tumor.
Epithelial-to-mesenchymal transition and estrogen receptor a mediated epithelial dedifferentiation mark the development of benign prostatic hyperplasia.
Clinically nonmetastatic renal cell carcinoma with sarcomatoid dedifferentiation: natural history and outcomes after surgical resection with curative intent.
Also, dedifferentiation with loss of radioiodine-avidity and finally anaplastic transformation are poor-prognosis events in DTC (2).
The analysis also identified molecules whose expression was associated with dedifferentiation (loss of differentiated phenotype) for some cancer types.
Occasional cases of dedifferentiation from a low-grade to a high-grade malignancy have been reported.