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n. Biology
Reversion of a specialized cell or tissue to an unspecialized form. Dedifferentiation may occur before the regeneration of appendages in plants and certain animals and in the development of some cancers.

de′dif·fer·en′ti·ate′ v.


(Biology) the reversion of the cells of differentiated tissue to a less specialized form


(diˌdɪf əˌrɛn ʃiˈeɪ ʃən)

n. Biol.
the loss of specialized form or condition previously acquired during development.
de`dif•fer•en′ti•ate`, v.i. -at•ed, -at•ing.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.dedifferentiation - the loss of specialization in form or function
adaption, adaptation, adjustment - the process of adapting to something (such as environmental conditions)
References in periodicals archive ?
Binding to the androgen receptors promotes proliferation and dedifferentiation of the prostatic epithelium.
Injury Induces Endogenous Reprogramming and Dedifferentiation of Neuronal Progenitors to Multipotency," Cell Stem Cell, 2017; DOI: 10.
Whether IGs result from dedifferentiation of mature glia or whether they are derived from neuroepithelial stem cells or progenitor cells--and if so, at precisely what stage of differentiation--has been a subject of great interest and study for decades.
sup][1],[4] Surgical complete excision is the mainstay and is rational for the prevention of recurrence and dedifferentiation, though dedifferentiation will not necessarily occur synchronously with recurrence.
This proposal is based on recent findings in the laboratory: The development of novel 3D spheroid system with chemically defined media allowing studies of chronic drug toxicity, relevant liver disease and liver function for 5 weeks in vitro, the finding of the role of miRNA in hepatocyte dedifferentiation and that hepatocytes during spheroid formation first de-differentiate but later in spheroids re-differentiate to an in vivo relevant phenotype.
Supratentorial low grade astrocytoma: prognostic factors, dedifferentiation, and the issue of early versus late surgery.
Supratentorial low-grade astrocytoma: prognostic factors, dedifferentiation, and the issue of early versus late surgery.
Dedifferentiated liposarcoma of the lower extremity with low-grade dedifferentiation and low-grade osteosarcomatous component.
2] A very small number of cases only have showed low grade areas of dedifferentiation.
If left unchecked, increased inflammation can then modulate the behavior of VSMCs by inducing their dedifferentiation.
The organogenic events occur by cellular differentiation, dedifferentiation and redifferentiation, depending on the resumption of the meristematic activity in the mature cells (MENDONCA et al.
Results: Prolonged epithelial cell CTGF overexpression results in upregulation of pro-fibrotic factors including fibronectin and PAI-1, upregulation of dedifferentiation maker, vimentin, and downregulation of expression of epithelial cell adhesion molecule, E-cadherin, compared to vector transduced controls.