degranulation

(redirected from degranulate)
Also found in: Medical.

de·gran·u·la·tion

 (dē-grăn′yə-lā′shən)
n.
The process of losing granules.

degranulation

(diːˌɡrænjʊˈleɪʃən)
n
a cellular process in which cytoplasmic granules within certain cells secrete their contents, often to the outside of the cell
References in periodicals archive ?
Bone marrow-derived murine mast cells migrate, but do not degranulate, in response to chemokines.
sup][8] In our patients, the RANTES level decreased at 4 h after beginning CPB, which was consistent with the simultaneously reduced lymphocyte counts, but not the activated and consumed platelets after cardiac surgery, which were supposed to degranulate abundant RANTES protein into the blood and cause higher plasma concentrations at 2-4 h after beginning CPB.
When the complement system is activated, the generation of anaphylatoxins C3a and C5a can degranulate mast cells.
The ear canal lining contains mast cells which degranulate (release granules) when exposed to an allergen.
2] (the major allergenic component and causes intravascular hemolysis), Peptide 401 (or mast cell degranulating peptide-causes mast cells to degranulate, releasing histamine and vasoactive amines), Apamin (a neurotoxin that acts on spinal cord), Adolapin (inhibits prostaglandin synthetase and Hyaluronidase (causes changes in cell permeability by altering cell membranes and disrupts collagen, allowing other venom components to penetrate into victim's tissues).
Packed with granules of histamine, heparin and other chemical mediators, mast cells degranulate, releasing their contents, in response to the presence of allergens.
Signal 3 tolerant CD8 T cells degranulate in response to antigen but lack granzyme B to mediate cytolysis.
These findings suggest that autoantibodies such as IgE anti-dsDNA and IgE autoantibodies against thyroid peroxidase (TPO) can also activate basophils to degranulate and play substantial roles in the pathogenesis of CSU.
After preincubation at 37[degrees]C for 15 min, MCs were stimulated to degranulate with compound 48/80 (5 mg/mL), a noncytotoxic, MC-specific stimulator, and incubation was continued for 1 min.
The ear canal lining contains mast cells which degranulate [release granules] when exposed to an allergen.
It seems possible that substances which degranulate mast cells are capable of inducing migraine attacks without clear experimental evidence (1).
Because so many of the symptoms of asthma are triggered by release of histamine when basophils and mast cells degranulate, this is one area of focus for clinical management and treatment.