Treatment focuses on minimizing mast cell degranulation
releases PGLYRP-1 that, multimerized with itself or complexed with PGN, potently activates TREM-1 causing pro-inflammatory cytokine release (Cho, 2006).
The main mechanism of mast cell degranulation
is through surface IgE cross-linking (Benoist & Mathis, 2002).
This leads to degranulation
of localized polymorphonuclear cells, inactivation of phagocytic cells and T lymphocytes.3 There is reduced response to A.actinomycetemcomitans and Staphylococcus species.
Moreover, all of them can cause lymphocyte degranulation
. The etiology of secondary HLH includes infection (especially Epstein-Barr virus infection), autoimmune diseases, and malignancies. The pathological features of HLH are mononuclear macrophages and tissue cells from the bone marrow, spleen, liver, or lymph nodes phagocytose hemocytes which form a phenomenon of hemophagocytosis.
"Once you stop the treatment, we expect patients to come back because we didn't cure the disease; we blocked the signs and symptoms by blocking mast cell degranulation
. Relapse after the last injection occurred at about 4 weeks with omalizumab versus 10 weeks for ligelizumab on average.
In addition, SP induces neutrophil infiltration and participates in inflammatory response through degranulation
In the present study, we showed that compound 48/80 induced dural mast cell degranulation
leads to vasodilation of middle meningeal artery and its anterior and posterior branches.
Sometimes mast cell tumors have history of shrinking and swelling related to intermittent mast cell degranulation
with histamine release.
It leads to mast cell degranulation
and release of various inflammatory mediators including histamine, cytokines, and leukotrienes.7,8 The inflammatory influx in the nasal mucosa results in structural aberrations that contribute to congestion, post nasal drip, concurrent sneezing, and nasal discharge leading to development of AR.9
Infiltrative anesthesia is to be avoided in case of mast cell disorders because of risk of degranulation
. Regarding scalp biopsy it is important to consider trichoglyphics and punch should be directed parallel to direction of emerging hair.10