general paralysis of the insane

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general paralysis of the insane

n
(Pathology) a disease of the central nervous system: a late manifestation of syphilis, often occurring up to 15 years after the original infection, characterized by mental deterioration, speech defects, and progressive paralysis. Abbreviation: GPI Also called: general paresis or dementia paralytica
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Wagner-Jauregg reported that a tuberculin injection caused long-term remission of psychotic and other symptoms of syphilis, which were called the "general paresis of the insane," or dementia paralytica.
Given its apparent success in treating dementia paralytica, a few clinicians went on to test the malaria pyrotherapy on schizophrenia patients.

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