Performed on a 1.5 T unit, T1WI MRI demonstrated bilateral hyperintense signal in the globus pallidus and in the substantia nigra, whereas T2WI and fluid attenuation inversion recovery (FLAIR) MRI showed bilateral hyperintense signal in the dentate nucleus
, crus cerebri and red nucleus, as well as in the periventricular white matter, corpus callosum and internal capsule (Fig.
Characteristic magnetic resonance imaging (MRI) findings including subcortical cerebral white matter (WM) abnormalities with T2 hyperintensities of the dentate nucleus
, globus pallidus, putamen was detected.
Drawings of the Golgi-impregnated multipolar neurons of the monkey dentate nucleus
were taken from the experimental data published in the book , in which is, also, described the histological procedure.
After being corrected with FDR simulations (p = 0.001, [alpha] = 0.05, cluster size = 326), we found that FA increased in the bilateral head of the caudate nucleus (HCN), lenticular nucleus (LN), ventral thalamus, substantia nigra (SN), red nucleus (RN), right dentate nucleus
(DN), and decreased in the mediodorsal thalamus and extensive white matter (Figure 1(a)).
MRI showed multiple symmetrical areas of altered signal intensity in bilateral centrum semiovale, corona radiata, basal ganglia, thalamus, midbrain, pons, medulla, cerebellar peduncles and dentate nucleus
of cerebellum, showing restriction of diffusion (Hyperintensity on DWI (Diffuse weighted MRI) and hypointense on ADC).
Fahr Syndrome is a rare disease where calcium and other minerals are stored bilaterally and symmetrically in the basal ganglia, cerebellar dentate nucleus
and white matter.
More precisely, these cerebellar regions are lateral portions of cerebellar hemispheres and the dentate nucleus
, which project to the cerebral cortex much more than any other cerebellar region, and thus, the term "neocerebellum" is used (10).