Increased ACTH causes hypokalemia, fluid retention, and hypertension as a consequence of deoxycorticosterone
Niemann et al., "Deficiency of the interleukin 17/23 axis accelerates renal injury in mice with deoxycorticosterone
acetate+angiotensin ii-induced hypertension," Hypertension, vol.
For instance, red wine polyphenols were reported to improve endothelial function and normalise blood pressure in NO-deficient hypertensive rats , in spontaneously hypertensive rats  and deoxycorticosterone
acetate- (DOCA-) salt-induced hypertensive rats .
Khalid, "Effects of naloxone, glycyrrhizic acid, dexamethasone and deoxycorticosterone
in repetitive stress," Clinical and Experimental Pharmacology and Physiology, vol.
In contrast to treatment with dexamethasone and testosterone, treatment with pure mineralocorticoid deoxycorticosterone
acetate did not suppress the long QT phenotype.
Typical characteristics of women with the lack of 17OH are primary amenorrhea, high levels of FSH, LH, progesterone, deoxycorticosterone
, hypertension and hyperpotassium alkalosis.
Table 1: Results of hormonal evaluation Patient's Female reference range value (follicular phase) Luteinizing hormone 56 1.9-9.2 U/L Follicle-stimulating hormone 145 3.5-9.2 U/L Estradiol <9.0 18-147 pg/mL Testosterone <0.02 0.084-0.481 ng/mL Dehydroepiandrosterone sulfate <2.5 98.8-340 [micro]g/dL Progesterone 5.8 0.25-0.54 ng/mL 17-OH progesterone <10 20-100 ng/dL Cortisol 0.9 5.4-28.7 [micro]g/dL Adrenocorticotropic hormone 185 6-76 pg/mL Deoxycorticosterone
54 2-19 ng/dL Aldosterone (supine) 0.5 2-9 ng/dL Plasma renin activity (supine) 0.1 0.2-1.6 ng/mL/h Anti-Mullerian hormone <0.2 For female: 1-10 ng/mL For male: 0.7-20 ng/mL
Protection against deoxycorticosterone
acetate-salt-induced hypertension and cardiovascular hypertrophy.
Methods: Hypertension was induced in mice by surgical removal of a kidney and by subcutaneous administration of a pellet with deoxycorticosterone
. Vasodilatation was measured in mesenteric arteries with a wire myograph.
In adrenals, Pcan be converted either into deoxycorticosterone
under the control of 21-hydroxylase or 17-OHP by 17, 20 lyase.
Malignant hypertension resulting from deoxycorticosterone
acetate and salt excess.
It addresses the prevalence and risk; the measurement of blood pressure; primary hypertension pathogenesis, natural history, and evaluation; the management of hypertension; treatment through lifestyle modifications and drug therapy; hypertensive emergencies; renal parenchymal and renovascular hypertension; primary aldosteronism; pheochromocytoma; hypertension induced by cortisol or deoxycorticosterone
; other forms of hypertension; and hypertension in pregnancy, childhood, and adolescence and in the context of the birth control pill.