cerevisiae) ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein TOR1A torsin family 1, member A (torsin A) PTPRK protein tyrosine phosphatase, receptor type, K SESN1 sestrin 1 TXLNA taxilin alpha DCK deoxycytidine
kinase RSU1 Ras suppressor protein 1 MTF2 metal response element binding transcription factor 2 SPAG7 sperm associated antigen 7 NCOA3 nuclear receptor coactivator 3 GFPT1 glutamine-fructose-6-phosphate transaminase 1 MBNL1 muscleblind-like (Drosophila) PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) NPC1 Niemann-Pick disease, type C1 ANO10 anoctamin 10 CDK7 cyclin-dependent kinase 7 B Gene Symbol Gene Title ELAC2 elaC homolog 2 (E.
Gemcitabine is a deoxycytidine
analog that exhibits anticancer activity against various solid tumors such as pancreatic cancer, lung cancer and prostate cancer (28,29).
TRE-515 is a novel, first-in-class inhibitor of deoxycytidine
kinase for the treatment of patients with myelodysplastic syndromes (MDS).
DCK is an enzyme that phosphorylates purines (deoxyadenosine and deoxygaunosine) and a pyrimidine (deoxycytidine
) as well as their analogues used as chemotherapeutic agents.
Guo et al., "Anti-tumor effect of 5aza-2;- deoxycytidine
by inhibiting telomerase activity in hepatocellular carcinoma cells," World Journal of Gastroenterology, vol.
A CpG site, a cytosine followed by a guanine, has the potential to be methylated, and measuring 5-methyl-2' deoxycytidine
(5-mdC) content across the genome by liquid chromatography/mass spectrometry (LC/MS) can provide an overall measure of genome-wide DNA methylation levels.
AID initiates recombination by conversion of multiple S region deoxycytidine
residues into deoxyuracil [90-93].
The most prevalent nucleotide was deoxycytidine
monophosphate, accounting for nearly 27% of all nucleotides within the studied MC4R gene sequence.
The EORTC Early Clinical Trials Cooperative Group experience with 5-aza-2'deoxycytidine
(NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomas.
Gemcitabine, 2', 2'-difluorodeoxycytidine, is an analogue of deoxycytidine
, a nuclesoside compound, which has antitumor activity against several solid tumors (Priami, 2009; Veltkamp et al., 2008).
Radu, Nathanson and their colleagues found that an important nucleotide called deoxycytidine
triphosphate (dCTP) is produced by two pathways, the de novo pathway and the nucleoside salvage pathway.
CleanAmp[TM] dGTP (TriLink BioTechnologies) was mixed with unmodified dATP, dCTP (deoxycytidine
triphosphate), and dTTP (deoxythymidine triphosphate) (Bioline) to limit extension of the template before temperature equilibration.