(2009) confirmed the antioxidant potential of purified phytic acid from corn germen through deoxyribose
and bathophenanthroline tests; they concluded that the antioxidant capacity grows with the increase in purified phytic acid concentration.
Presence of these phenolic contents in litchi exhibit excellent antioxidant activity and they are effective in scavenging superoxide anion radicals and inhibiting deoxyribose
Protection of deoxyribose
and DNA from degradation brought about by aqueous extracts of several wild plants.
These hydroxyl free radicals participate in the oxidation of the deoxyribose
moiety, followed by the hydrolytic cleavage of the sugar phosphate backbone .
It stimulates the hexose monophosphate (HMP) shunt, a series of biochemical reactions that convert 6-carbon sugar (glucose) into 5-carbon sugars (ribose and deoxyribose
O[H.sup.o] were generated by incubating the following reagents in a final volume of 1.2 ml 10 mM K[H.sub.2]P[O.sub.4]-KOH buffer (pH 7.4) at 37[degrees]C for 60 min: 1.4 mM [H.sub.2][O.sub.2], 100 [micro]M Fe[Cl.sub.3] and 2.8 mM deoxyribose
, 100 [micro]M EDTA, and 100 [micro]M ascorbic acid in presence or absence (control) of the extract.
Trichloroacetic acid (TCA), deoxyribose
, ascorbic acid and other chemicals were purchased from M/s Sisco Research Laboratories, Mumbai, India.
Each nucleotide comprises a sugar component (deoxyribose
), a phosphate component, and one of four different bases--adenine (A), guanine (G), thymine (T), and cytosine (C).
Cyclopurine nucleosides would be expected to induce alterations in the conformational structure of the DNA backbone as a consequence of the covalent bond formed between the C-8 of purines and C'-5 of the deoxyribose
Each nucleotide consists of two subunits: (1) a modified sugar molecule (i.e., deoxyribose
phosphate) and (2) one of four molecules known as organic bases called adenine (A), thymine (T), guanine (G), and cytosine (C).
These results are in accordance with previous studies on antioxidant activity of Smilax species extracts, which presented diverse mechanisms of action, such as quenching of superoxide anion, lipid peroxidation inhibition, deoxyribose
degradation inhibition, and reducing power [29, 55].
ROS can trigger oxidation of deoxyribose
, damage of the DNA chain and deletion of nucleotides.