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Noun1.deoxythymidine - a nucleoside component of DNA; composed of thymine and deoxyribose
nucleoside - a glycoside formed by partial hydrolysis of a nucleic acid
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References in periodicals archive ?
The siRNA target sequences for CHOP were as follows: GAA UCU AAU ACG UCG AUC AdTdT (dT is deoxythymidine).
This allows the phosphorylation of deoxythymidine - a precursor for deoxythymidine triphosphate which is used in DNA synthesis.
The SNP allele identification (5 [micro]L) was 1 [micro]L digested PCR product; 0.01-0.6 [micro]M of each primer (Supplementary Table S1); 3.5 mM MgC[L.sub.2], 1 x Thermo Sequenase DNA polymerase buffer; 0.5 [micro]M fluorescein-labeled 2,3-dideoxycytidine-5' triphosphate (ddCTP) (PerkinElmer Life and Analytical Sciences, USA); 0.5 [micro]M each unlabeled deoxyguanosine triphosphate (dGTP), deoxythymidine triphosphate (dTTP), and deoxyadenosine triphosphate (dATP); and 1 U Thermo Sequenase DNA Polymerase (GE Healthcare, UK).
Folate is an essential nutrient acting as methyl donor for conversion of deoxyuridine monophosphate (dUMP)to deoxythymidine monophosphate required for DNA synthesis and repair.
In folate pathway mechanism deoxythymidine monophosphate (dTMP) (dTMP) is produced from deoxyuridine monophosphate (dUMP) by oxidation of tetrahydrofolate to dihydrofolate catalysed by dihydrofolate reductase (DHFR) (Hyde 2005; Abali et al.
CleanAmp[TM] dGTP (TriLink BioTechnologies) was mixed with unmodified dATP, dCTP (deoxycytidine triphosphate), and dTTP (deoxythymidine triphosphate) (Bioline) to limit extension of the template before temperature equilibration.
Thus, through direct inhibition by MTX and due to lack of FH4 and accumulation of FH2, deoxythymidine monophosphate synthesis and purine de novo synthesis is blocked, which eventually lead to leukemic cell death, bone marrow suppression, gastrointestinal mucositis, liver toxicity, and, rarely, alopecia [14, 15, 18, 19].