deoxythymidine monophosphate


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Related to deoxythymidine monophosphate: thymidylic acid
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Noun1.deoxythymidine monophosphate - one of the four nucleotides used in building DNA; all four nucleotides have a common phosphate group and a sugar (ribose)
nucleotide, base - a phosphoric ester of a nucleoside; the basic structural unit of nucleic acids (DNA or RNA)
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In folate pathway mechanism deoxythymidine monophosphate (dTMP) (dTMP) is produced from deoxyuridine monophosphate (dUMP) by oxidation of tetrahydrofolate to dihydrofolate catalysed by dihydrofolate reductase (DHFR) (Hyde 2005; Abali et al.
In this reaction, one carbon group of the 5,10-MTHF is transferred to a molecule called deoxyuridine monophosphate (dUMP), resulting in the formation of deoxythymidine monophosphate (dTMP) and dihydrofolate (DHF).
Thymidylate synthase (TS) is a homodimer of approximately 72 kDa which catalyzes the reductive methylation of 2-deoxyuridine monophosphate (dUMP) using 5,10-methylenetetrahydrofolate ([CH.sub.2][H.sub.4]folate) to form deoxythymidine monophosphate (dTMP) and dihydrofolate ([H.sub.2]folate).