MiR-204/miR-211 downregulation contributes to candidemia-induced kidney injuries via derepression
of Hmx1 expression.
It has been reported that Hdac3 was required for transcriptional activation of retinoic acid response element. Cells derived from Hdac3 knockout mice displayed both downregulation and upregulation of gene expression. Furthermore, gene expression profiling studies comparing the cells treated with HDAC inhibitors versus those untreated revealed that the number of genes downregulated were comparable to those upregulated. One possibility is that Hdac3 may prohibit transcription of transcriptional repressors, leading to derepression
of gene expression.
(40) The Hh pathway may be activated via a canonical or noncanonical mode of action: in canonical Hh signaling, binding of the Hh ligands to their receptor leads to the derepression
of smoothened (SMO), resulting in the activation of glioma-associated oncogene homolog (GLI)1, GLI2, and GLI3 transcription factors; on the other side, in noncanonical Hh signaling, GLI activity is regulated independently of SMO by other signaling pathways, including TGF-[beta].
PGE2 induces interleukin-8 derepression
in human astrocytoma through coordinated DNA demethylation and histone hyperacetylation.
AmpC [beta]-lactamase production returns to low levels after antibiotic exposure is discontinued, unless spontaneous mutations occur in the AmpD locus of the gene, leading to permanent hyperproduction (derepression
has been associated previously with structural defects within the ampD gene or with decreased ampD expression.
In mouse ESCs, the absence of replacement histone variant H3.3, which is important for cell fate decision in early embryos , leads to reduced repressing histone mark and upregulated ERV expression, causing derepression
of endogenous genes in vicinity .
Lin et al., "Derepression
of BDNF transcription involves calcium-dependent phosphorylation of MeCP2," Science, vol.
of CDKN2A (cyclin-dependent kinase inhibitor 2A) locus, which encode for both p16 and p14, is another trigger for senescence associated with aging and is responsible of the increased expression of p16 in aged tissues  and one of the most prominent indicators of the presence of senescent cells in aged tissues .
aeruginosa and restores susceptibility to ceftazidime in isolates in which the mechanism of resistance is that of stable derepression
of that enzyme.
The effects on betalactam susceptibility of phenotypic induction and genotypic derepression
of beta-lactamase synthesis.
The observed antitumor effect was associated with the derepression
of 5' AMP-activated protein kinase (AMPK), which in turn led to the inhibition of both mammalian target of rapamycin complex 1 (mTORC1) and its regulatory target fascin actin-bundling protein 1 (FSCN1).