[2,3] In the literature, complaints or symptoms reported by more than 25% of patients with FM include widespread body pain, fatigue, morning stiffness, headache, paresthesia, sleep disturbance, subjective swelling, dry mouth, loss of libido, irritable bowel, dysmenorrhea, joint hypermobility, temporo-mandibular joint dysfunction, dermographism
, Raynaud's phenomenon, and reticular color changes in skin.
Allakos announced "positive" Phase 2 results from two additional chronic urticaria cohorts: patients with cholinergic urticaria and symptomatic dermographism
. Earlier this month, Allakos reported that 12 of 13 patients in the Xolair-naive chronic spontaneous urticaria, or CSU, cohort achieved a complete response with AK002.
The disease-related parameters included: disease duration, concomitant angioedema, concomitant dermographism
, concomitant non-steroidal antiinflammatory drug (NSAID) hypersensitivity, concomitant atopy (rhinitis, asthma, and dermatitis), autologous serum skin test (ASST) positivity, weekly urticarial activity score (UAS7), dermatology life quality index (DLQI), treatments administered before the omalizumab treatment, treatments administered concurrently with the omalizumab treatment, and side effects observed during the omalizumab treatment.
Forty-seven percent of patients experienced angioedema and 33% had inducible urticaria, most commonly brought forth by pressure or dermographism
. One-third of patients had previously been on cyclosporine and half of the patients had a high D-Dimer level.
We used the histamine dihydrochloride (10 mg/ml) as a positive control to ensure skin reactivity and glycerol containing the diluent of the prick test solution as a negative control to eliminate dermographism
. We considered a test positive ifthe wheal diameter obtained was 3 mm greater than the negative control and/or 50% greater than the diameter of the positive control.
He also had linear edematous erythematous wheal lesions, similar to dermographism
in appearance on his back and shoulders (Figure 1).
and atopy in patients with Behcet's disease.
In the first recognition of the disease, Bywaters described urticariform rash and dermographism
In case of symptomatic dermographism
, elicit dermographism
by stroking skin firmly with a tongue depressor or, if available, use a Fric test.
In mastocytosis, itching, dermographism
, eryhtema attacks in the whole body, bulla formation, gastrointestinal complaints including nausea, abdominal pain, diarrhea and colic and rarely respiratory distress, headache, malaise, lethargy and neuropsychiatric findings may be observed.
The clinical picture associated with thermal crisis can include local or general symptoms such as anorexia, sleep disturbances, irritability, hot and cold intolerance, changes in libido, limb paresthesia, muscle tone changes, tremors, and dermographism
. (10) However, none of these symptoms was evident in our patient.
DISCUSSION: The principle indications for the use of second generation H1 receptor antagonists are in the treatment of disease with inflammatory component like allergic rhinitis, conjunctivitis, idiopathic urticarial and diseases of allergic nature like hayfever (24), pollinosis (25), dermographism
(26) and atopic eczema (27).