Estrogens promote cell-cell adhesion of normal and malignant mammary cells through increased desmosome
Adhesion between corneocytes is assumed to occur by the desmosome
apparatus (corneodesmosome), composed of desmosomal cadherin, armadillo proteins, and plakins.
They interact with plakoglobin, desmoplakin, and plakophilin that are involved in desmosome
assembly and the anchoring of intermediate filaments of desmin .
(5) These symptoms depend on the sites of impaired desmosome
function and usually vary in their presentation, such as oral pain, stinging, sore throat, hoarseness, dysphonia, dysphagia, odynophagia, epistaxis, nasal congestion, blood-tinged mucus, otalgia, ear canal obstruction, vaginal discharge and pain, ocular pain, and excessive tearing.
Results are expressed as means [+ or -] SEM of desmosome
protein (desm) and Ki-67 positive cells per area ([mm.sup.2]) (n = 7).
As revealed in Figure 4, hepatic lobular architecture was clear and tightly aligned with large blue-hued nucleus that was seen in control mice, while the hepatic samples from NDEA-challenged mice presented nuclear fragmentation, cytoplasm condenses, fragmented desmosome
complexes, and cell separated from whose neighbors.
We argued that the LEKTI deficient expression and the increased KLK5, 7 expressions in the keratinocytes under imbalance Th1/Th2 cytokines may lead desmosome
cleavage and abnormal FLG expression and processing and induce the impairment the skin barrier, though Hatano et al.
Increased lipogenesis, damage of desmosome
structure, and PPAR-gamma activation were observed in the patientspecific iPSC-derived cardiomyocytes.
However, when we isolated desmosome
molecules and characterized them we found that they are actually much more flexible than those of the other junctions -- the total opposite to what people had thought!"
It is characterized by immunoglobulin G auto antibodies against desmosome
associated protein antigens (desmoglein 1 and/or 3) found in epithelial and epidermal intercellular substance.
The zinc-finger protein slug causes desmosome
dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition.
Skin fragility in these mice, and in humans with AEC syndrome, was associated with altered desmosome
gene expression mediated by mutant p63 .