CTP-692 is a deuterated
form of D-serine, an endogenous, required co-agonist of the N-methyl-D-aspartate (NDMA) receptor.
Lot 3 deuterated
reagents cpv sub-code: 33696400-9 isotopic reagents (rev.
15) Utilizing this knowledge, a deuterated
form of tetrabenazine, deutetrabenazine, was synthesized with such a purpose in mind.
3]CN), diethyl ether, deuterated
solvents, benzophenone, MMA, 2-HEMA, allyl 2bromo-2-methylpropionate (ABIB), copper (I) bromide (CuBr), copper (I) chloride (CuCl), 2,2'-bipyridyl (Bpy), N,N,N',N',N"-pentamethyldiethylenetriamine (PMDETA), chromatographic stationary phases (neutral and basic aluminium oxide), phosphate buffer saline (PBS), BDP, and poly(2-hydroxyethyl methacrylate) (PHEMA, Mv ~ 20,000) were all purchased from Sigma-Aldrich.
The product was previously know under the developmental name, SD-809, and has now become the first deuterated
product to get FDA approval and also the second drug approved in Huntington's disease.
5 ml Eppendorf reaction tube, 1 ml of deuterated
DMSO containing 0.
Analyte identification was based on correct retention time and product ion ratio relative to standards (PEth 16:0/18:1 from Med Chem 101; PEth 16:0/16:0 from Avanti Polar Lipids) at 5-5000 pg/sample and a deuterated
internal standard (PEth 16:0/[18:1-d.
Other pipeline candidates include deuterated
versions of pirfenidone for idiopathic pulmonary fibrosis and levodopa for Parkinson's disease.
As the deuterated
form is heavier than normal water, it is less easily lost into space through evaporation.
To match specific sampling and application needs, a selection of mercury cadmium telluride or deuterated
triglycine sulfate detectors is available.
chloroform was used as a solvent and tetramethylsilane was used as an internal standard.
The samples were prepared in deuterated