System-dependent effects of specific deuteration
with aldehyde oxidase cleared drugs," Drug Metabolism and Disposition, vol.
However, the deuteration
positions were not identified.
Effect of W-methyl deuteration
on metabolism and pharmacokinetics of enzalutamide.
At first, aromatic ring protons of Tyr and His residues (twelve each) were used for monitoring the conformational change of the T[F.sub.1][beta] monomer on nucleotide binding in solution, because of their relatively sharp NMR signals on deuteration
of the other ring protons.
in 2h) as observed by [sup.1]H-NMR spectroscopy).
Noirault et al., "Isotopic effect study of propofol deuteration
on the metabolism, activity, and toxicity of the anesthetic," Journal of Medicinal Chemistry, vol.
The intensity of molecular ion in the mass spectra of porphyrin has also been used in the study of deuteration
(as a general example of electrophilic substitution) of porphyrins, metalloporphyrins, and some reduced derivatives.
of the methyl groups gave insight into the packing of the micelle core (1).
The lower intensities of the bands close to 1582 and 1565 [cm.sup.-1] observed at [p.sup.2]H 4.0 may be ascribed to deuteration
, at least partial, of ionized carboxyl group of aspartic and glutamic acid (Barth 2000).
of chloroform to deuterochloroform (CD[Cl.sub.3]) decreases its metabolic rate, thereby reducing liver and lung toxicity in rats by five to seventy percent over chloroform.
Subpicosecond spectroscopy of liquid water in the infrared: Effect of deuteration
on the structural and vibrational dynamics.