dicumarol


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dicumarol

(daɪˈkuːməˌrɒl)
n
(in the US) another name for dicoumarol
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

di•cu•ma•rol

or di•cou•ma•rol

(daɪˈku məˈrɔl, -ˌrɒl, -ˈkyu-)

n.
a synthetic coumarin derivative, C19H12O6, used chiefly to prevent blood clots.
[resp. of di-1 + coumar(in) + -ol1]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.dicumarol - an anticoagulant drug that has now been largely replaced by warfarin
anticoagulant medication, decoagulant - medicine that prevents or retards the clotting of blood
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Link, "The discovery of dicumarol and its sequels," Circulation, vol.
Before measurement, hepatocytes stimulated with methylcholanthrene (3-MC, Sigma Aldrich, Seelze, Germany) for 72 hours were treated with 8 [micro]M ethoxyresorufin (Molecular Probes, Eugene, USA) and 10 [micro]M dicumarol (Sigma Aldrich, Seelze, Germany) for 1h (37[degrees]C, 5% C[O.sub.2]).
The assay was based on the activities for NAD(P)H-dependent reduction of DCPIP at 600 nm and the reaction was specifically inhibited by dicumarol. The NQO1 activity was thus measured as the dicumarol-inhibitable reduction in absorbance at 600 nm and was expressed as nmole DCPIP reduced/min/mg protein.
7-ethoxyresorufin, 7-benzyloxyresorufin, resorufin, H33258, salicylamide, dicumarol) were purchased from Sigma (St.
Behavioral effects of manganese injected in the rat substantia nigra are potentiated by dicumarol, a DT-diaphorase inhibitor.
Local haemorrhage and necrosis of the skin and underlying tissues, during anti-coagulant therapy with dicumarol or dicumacyl.
Good examples of vitamin antagonists include isonicotinic acid hydrazide (antagonist of pyridoxine), aminopterin (folate antagonist), dicumarol (vitamin K antagonist), and avidin (interferes with biotin absorption).