They have since been associated with patients who are human immunodeficiency virus (HIV) infected, taking antiviral medications (including didanosine
, acyclovir, ganciclovir) or immunosuppressants (including tacrolimus and mycophenolate).
Lucidi was also worldwide vice president Virology & Oncology at Johnson & Johnson, where he led portfolio strategy from drug discovery to market and served in senior leadership at Bristol-Myers Squibb, where he was responsible for the strategy and launch of several new antiviral and oncology products, includingVidex (didanosine
), Zerit (stavudine), Paraplatin (carboplatin) andTaxol (paclitaxel).
He was worldwide vice-president virology & oncology at Johnson & Johnson where he led portfolio strategy from drug discovery to market, and served in senior leadership at Bristol-Myers Squibb where he was responsible for the strategy and launch of several new antiviral and oncology products, including but not limited to Videx (didanosine
), Zerit (stavudine), Paraplatin (carboplatin) and Taxol (paclitaxel).
 In a previous study, pancreatitis was associated with gallstones, intravenous drug abuse, pentamidine intake, and Pneumocystis jiroveci and Mycobacterium avium-intracellulare infections.'81 Acute pancreatitis is also a complication of nucleoside reverse transcriptase inhibitors (didanosine
Finally, older age was associated with low HDL-cholesterol (OR: 1.35, 95% CI: 1.08-1.69; p = 0.009), while exposure to didanosine
> 6 months (OR: 0.08, 95% CI: 0.02-0.43; p = 0.003) and being male (OR: 0.16, 95% CI: 0.05-0.57; p = 0.005) decreased the risk of having low HDL-cholesterol.
The main reasons for switching to ABC were (a) lipodystrophy and lipid abnormalities in patients treated with zidovudine (27 patients); (b) to avoid tenofovir related toxicity (38 patients); stavudine and didanosine
replacement (10 patients).
Several cases of ototoxicity have been reported in HIV infected patients treated with zalcitabine (Martinez and French, 1993); didanosine
(Colebunders, Dipraetere, Van Wanzeele, and Van Gehuchten, 1998); zidovudine and didanosine
(Christensen et al, 1998); stavudine, lamivudine, didanosine
and hydroxyurea (Simdon et al, 2001); and post exposure prophylaxis with stavudine, lamivudine and nevirapine (Rey et al, 2002).
Nevirapine, zidovudine, and didanosine
compared with zidovudine and didanosine
in patients with HIV-1 infection.
(5.) Martinez E, Milinkovic A, de Lazzari E, Ravasi G, et al, Pancreatic toxic effects associated with co-administration of didanosine
and tenofovir in HIV-infected adults.
First-line ART combinations were non-nucleoside reverse-transcriptase inhibitors (NNRTI) (nevirapine [NVP] or efavirenz [EFV]) plus 2 nucleoside reverse-transcriptase inhibitors (NRTIs), often stavudine (d4T), didanosine
(DDI), zidovudine (AZT), tenofovir (TDF), or abacavir (ABC) plus lamivudine (3TC).
And so Bongani, weak and wasted, with histoplasmosis of the palate, was our first patient to receive didanosine
(which he paid for) and hydroxyurea (which we supplied).