diethylstilbestrol

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di·eth·yl·stil·bes·trol

(dī-ĕth′əl-stĭl-bĕs′trôl′, -trōl′)

n. Abbr. DES

A nonsteroidal synthetic drug, C₁₈H₂₀O₂, having estrogenic properties and used in the treatment of advanced prostate cancer. Before 1971 it was prescribed to prevent miscarriage and to treat menstrual disorders but was found to cause vaginal cancer and other reproductive abnormalities in the daughters of pregnant women so treated.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

diethylstilbestrol

(daɪˌɛθɪlstɪlˈbɛstrɒl; -ˌiːθaɪl-) or

diethylstilboestrol

(Biochemistry) a synthetic hormone with oestrogenic properties, used to relieve menopausal symptoms. Formula: OHC6H4CH:CHC6H4OH. Also called: stilbestrol or stilboestrol

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

di•eth•yl•stil•bes•trol

(daɪˌɛθ əl stɪlˈbɛs trɔl, -trɒl)

n.

a synthetic estrogen, C₁₈H₂₀O₂, found to be carcinogenic to offspring when used to support pregnancy and now restricted in use. Abbr.: DES

[1935–40; di-¹ + ethyl + stilbestrol (stilb(ene) + estr(us) + -ol¹)]

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Noun

diethylstilbestrol - a potent estrogen used in medicine and in feed for livestock and poultry

DES, diethylstilboestrol, stilbestrol, stilboestrol

estrogen, oestrogen - a general term for female steroid sex hormones that are secreted by the ovary and responsible for typical female sexual characteristics

Translations

diethylstilbestrol (DES)

n dietilestilbestrol m (DES)

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References in periodicals archive ?

The synthetic hormone, diethylstilbestrol (DES) was withdrawn in the 1970s when it was found to be associated with vaginal cancer and fertility disorders among the women who took it.

Hormone drug linked to birth defects in boys

High-dose intravenous diethylstilbestrol has been successfull in treating disseminated intravascular coagulation of acute onset in several patients with widespread cancer of the prostate.(5) In this case report it is interesting to note that the patient's bleeding stopped after standard oral doses of diethylstilbestrol.

Gingival bleeding: initial presentation of prostatic cancer

Do not increase the screening interval beyond annual testing for women who are HIV-positive, who are immunosuppressed, who were exposed in utero to diethylstilbestrol, or who have been treated for CIN 2 or 3 or adenocarcinoma in situ.

Keep annual screening for women who have a history of CIN, HIV, or certain chronic conditions

Data from one study of nearly 1,500 women conducted by the National Institute of Environmental Health Sciences identified prenatal diethylstilbestrol (DES) exposure and young age at menarche as fibroid risk factors, reported Donna Day Baird, Ph.D.

Alcohol use, DES exposure tied to risk of fibroids

Diethylstilbestrol (DES), a highly potent, orally available synthetic estrogen, is perhaps the most studied among the class of exogenous estrogens since being strongly associated with vaginal adenocarcinoma and abnormalities of the uterus and cervix in young women who were exposed via pharmacological use by their mothers during pregnancy (Herbst et al.

Estrogen Receptor-[alpha] mediates diethylstilbestrol-induced feminization of the seminal vesicle in male mice

He first became interested in livestock hormones in the early 1970s, when he learned that farmers were giving the synthetic hormone diethylstilbestrol (DES) to chickens and cattle.

Hormones: here's the beef: environmental concerns reemerge over steroids given to livestock

In utero exposure to diethylstilbestrol (DES), maternal prepregnancy or gestational diabetes, and having been born from a monozygotic multiple birth were most strongly associated with early-onset fibroids.

Uterine fibroids in black women

Washington, May 29 (ANI): Exposure in the womb to chemicals like Bisphenol-A (BPA) and Diethylstilbestrol (DES) can increase an offspring's risk of breast cancer, according to a new study.

Prenatal exposure to BPA may raise breast cancer risk

Medical research indicates that daughters of women who took the drug diethylstilbestrol (DES), during the years 1938 through 1971 to prevent miscarriage, have an increased risk of developing this disease.

Endometriosis; Overview

The type of estrogen treatment was unknown for 25 women, but in all other cases the treated women had been prescribed diethylstilbestrol (DES) or ethinyl estradiol; DES was in use before 1971.

Estrogen used to suppress growth in adolescence linked to later infertility

Screen more frequently those who are HIV-positive, are immunosuppressed, are cervical cancer survivors, or were exposed to diethylstilbestrol in utero.

Annual Pap not for all women, ACOG revised guidelines say: intervals of 2-3 years

Other mice received comparable doses of diethylstilbestrol (DES), a synthetic estrogen known to cause cancer.