diethylstilbestrol


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di·eth·yl·stil·bes·trol

 (dī-ĕth′əl-stĭl-bĕs′trôl′, -trōl′)
n. Abbr. DES
A nonsteroidal synthetic drug, C18H20O2, having estrogenic properties and used in the treatment of advanced prostate cancer. Before 1971 it was prescribed to prevent miscarriage and to treat menstrual disorders but was found to cause vaginal cancer and other reproductive abnormalities in the daughters of pregnant women so treated.

diethylstilbestrol

(daɪˌɛθɪlstɪlˈbɛstrɒl; -ˌiːθaɪl-) or

diethylstilboestrol

n
(Biochemistry) a synthetic hormone with oestrogenic properties, used to relieve menopausal symptoms. Formula: OHC6H4CH:CHC6H4OH. Also called: stilbestrol or stilboestrol

di•eth•yl•stil•bes•trol

(daɪˌɛθ əl stɪlˈbɛs trɔl, -trɒl)

n.
a synthetic estrogen, C18H20O2, found to be carcinogenic to offspring when used to support pregnancy and now restricted in use. Abbr.: DES
[1935–40; di-1 + ethyl + stilbestrol (stilb(ene) + estr(us) + -ol1)]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.diethylstilbestrol - a potent estrogen used in medicine and in feed for livestock and poultry
DES, diethylstilboestrol, stilbestrol, stilboestrol
estrogen, oestrogen - a general term for female steroid sex hormones that are secreted by the ovary and responsible for typical female sexual characteristics
Translations

diethylstilbestrol (DES)

n dietilestilbestrol m (DES)
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References in periodicals archive ?
Other risk factors include: exposure to diethylstilbestrol (DES) as a foetus during pregnancy, vaginal adenosis, uterine prolapse, previous cervical dysplasia or a previous invasive lesion.
Primary vaginal adenocarcinoma with bicornuate bicollis uterus with renal involvement: a rare case report
Adverse health outcomes in women exposed in utero to diethylstilbestrol.
Screening for chemical contributions to breast cancer risk: a case study for chemical safety evaluation
Among drugs, diethylstilbestrol, anti-epileptic drugs, and neuroleptic agents binding barbiturate or benzodiazepine receptors.
Prenatal exposures to environmental agents or drugs promote the development of diseases later in life
Primary clear cell carcinoma of the vagina that is not related to in utero diethylstilbestrol use.
Non-diethylstilbestrol-associated primary clear cell carcinoma of the vagina: two case reports with immunohistochemical studies and literature review
Does the administration of diethylstilbestrol during pregnancy have therapeutic value?
DES: 40 years of research with more to learn
Leuprolide versus diethylstilbestrol for metastatic prostatic cancer.
Bilateral orchiectomy with or without flutamide for advanced carcinoma prostate
Oxidation of catechols to semiquinones and quinones is a mechanism of tumor initiation not only for endogenous estrogens, but also for synthetic estrogens such as hexestrol and diethylstilbestrol, a human carcinogen.
Catechol quinones of estrogens in the initiation of breast, prostate, and other human cancers: keynote lecture
The first synthetic estrogen, diethylstilbestrol (DES), for example, is an endocrine disrupter.
Editor's note
Research also indicates that daughters of women who took the drug diethylstilbestrol (DES) between 1938 and 1971 to prevent miscarriage have an increased risk of endometriosis.
Endometriosis; Overview
Standards of trans-resveratrol (99% purity), trans 3,4', 5-trihydroxystilbene-3-[beta]-D-glucopyranoside (trans-piceid) (97% purity), diethylstilbestrol ([greater than or equal to] 99% purity), diethylstilbestrol dipropionate, dienestrol, hexestrol ([greater than or equal to]98% purity), and human blank LDL were purchased from Sigma-Aldrich.
HPLC-tandem mass spectrometric method to characterize resveratrol metabolism in humans
Certain risks associated with prenatal exposure to diethylstilbestrol (DES) may be carried over to the next generation, according to results of a study of 463 women whose mothers had been exposed to DES prenatally and 330 whose mothers had not been exposed to the drug.
Can des risk be passed on?
Diethylstilbestrol (DES) Retailer: Wedgewood Pharmacy wedgewoodpharmacy.
Drips dried: don't give up; your dog's urinary incontinence can be cured

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