Testosterone, for its action in peripheral tissues, has to be converted to dihydrotestosterone
by the action of an enzyme called 5-alpha reducatse.5 This is the key enzyme in male sex differentiation.
Researchers conducted three experiments to assess the effects of prenatal exposure to dihydrotestosterone
, as well as maternal obesity, in mice.
formation in pseudovaginal perineoscrotal hypospadias.
Insulin appears to decrease hepatic production of sex-hormone binding globulin, which leads to higher circulating levels of unbound, active androgen, triggering all the well-established androgen effects of proliferation and differentiation of sebocytes as well as upregulation of lipid production." (9) "The skin of acne patients shows greater activity of 5-a-reductase, the enzyme that converts testosterone to a more potent, androgen dihydrotestosterone
. This increased activity is independent of androgens and explains the poor correlation between systemic levels of androgens and the severity of acne lesions.
Nagai et al., "Urine steroid hormone profile analysis in cytochrome P450 oxidoreductase deficiency: implication for the backdoor pathway to dihydrotestosterone
," The Journal of Clinical Endocrinology & Metabolism, vol.
Sunetics is a hair-growth laser that heals the follicle, increases cellular activity and kills hormone dihydrotestosterone
or DHT (which, in time, stops the follicle from producing hair).
For both genders, pattern hair loss is the most common type, usually associated with an excess of the male hormone dihydrotestosterone
, or DHT.
(DHT) (1 x [10.sup.-12] - 1 x [10.sup.-07]M) and 17[beta]-estradiol (E2) (1 x [10.sup.-13] - 1 x [10.sup.-09]M) were used as positive controls for the AR and ER[alpha] CALUX, respectively.
The hemizygous mutations in the AR (Xq11.2-q12) encoding AR are associated with X-linked androgen insensitivity, and bi-allelic mutations in SRD5A2 cause enzyme deficiency, converting testosterone (T) to dihydrotestosterone
Natural hormone testosterone (T) and dihydrotestosterone
(DHT), known as androgens, are the endogenous ligands of AR.
Hereditary hair loss in Men and Women is caused by the action of the hormone dihydrotestosterone
(DHT) on genetically susceptible scalp hair follicles.
is the main hormone responsible for androgenetic alopecia in people who are genetically susceptible.