diiodotyrosine

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Related to diiodotyrosine: Monoiodotyrosine

di`i`o`do`tyr´o`sine

(Chem., Med.) a chemical substance consisting of tyrosine with two hydrogen atoms on the benzene ring replaced by iodine atoms.

References in periodicals archive ?

Thyroglobulin contains 140 tyrosine residues and serves as the matrix to which reactive iodine is attached to form monoiodotyrosine (MIT) and diiodotyrosine (DIT).

Thyroid function test: a clinical lab perspective

The tyrosines are iodinated at one (monoiodotyrosine) or two (diiodotyrosine) sites and then coupled to form the active thyroid hormones, tetraiodothyronine or thryoxine ([T.sub.4]) and triiodothyronine ([T.sub.3]).

Iodine

Thyroid peroxidase first oxidizes iodide to iodine and then iodinates tyrosines on thyroglobulin to produce monoiodotyrosine and diiodotyrosine. Thyroid peroxidase finally links two iodinated tyrosines to produce [T.sub.4] and [T.sub.3].