diltiazem


Also found in: Thesaurus, Medical, Acronyms, Wikipedia.
Related to diltiazem: Diltiazem hcl

dil·ti·a·zem

 (dĭl-tī′ə-zĕm′)
n.
A calcium channel blocker drug, C22H26N2O4S, that acts as a coronary vasodilator and is used in the form of its hydrochloride to treat angina pectoris and hypertension.

[(vaso)dil(ator) + -tiazem, suff. for calcium channel blockers (shortening and alteration of benzothiazepine, class of compounds : benzo- + thi(o)- + az(o)- + ep(oxide) + -ine).]

diltiazem

(dɪlˈtaɪəˌzɛm)
n
(Pharmacology) a benzothiapine and a calcium channel blocker, used to treat angina and arrhythmia
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.diltiazem - a calcium blocker (trade name Cardizem) used in treating hypertension or angina or heart failure
calcium blocker, calcium-channel blocker - any of a class of drugs that block the flow of the electrolyte calcium (either in nerve cell conduction or smooth muscle contraction of the heart); has been used in the treatment of angina or arrhythmia or hypertension or migraine
Translations

diltiazem

n diltiazem m
References in periodicals archive ?
Objective: To study the effect of diltiazem on monosodium glutamate induced histomorphological changes in the fallopian tube.
Medically, treatment consists of increased water intake, incorporation of more fiber in the diet, undertaking warm baths a couple times a day, and application of a pea-sized amount of topical 2 percent diltiazem three times daily on the outside of the anus for 6-8 weeks.
Recent several studies have pointed the efficiency of Calcium channel blockers like Diltiazem by virtue of their properties, direct vasodilation and negative chronotropic and dromotropic effects.8910 Therefore, comparison of the effects of intravenous Diltiazem and intravenous Lignocaine, a more commonly used agent, on blunting the pressor responses to endotracheal intubation was done in our study.
Diltiazem (Sigma-Aldrich Ltd, Gillingham, UK) diluted with 0.9% saline solution was infused at 100 [micro]mol/kg/min intravenously, increased to approximately 120-200 [micro]mol/kg/min until a satisfactory chronotropic response was achieved (reduction of >10% in heart rate) or the upper limit was reached.
Medically, treatment consists of increased water intake, incorporation of more fiber in the diet, undertaking warm sitz baths a couple times a day, and application of a pea-sized amount of topical 2% diltiazem three times daily on the outside of the anus for 6-8 weeks.
The US Food and Drug Administration (FDA) approved diltiazem hydrochloride (Tiadylt ER) extended release capsules to be marketed in multiple strengths of 120mg, 180mg, 240mg, 300mg and 420mg.
CYP 3A4 inhibitors including calcium channel blockers like diltiazem are also widely prescribed and they increase plasma levels of statins [6, 7].
Few case reports suggest that CCBs precipitate intracerebral bleeding2 or may predispose to other hemorrhagic problems like gastrointestinal3,4,5 or surgical bleeding.6 Calcium channel blockers may cause vasculitis as their side effect.7 There are also reports of CCBs like diltiazem causing lichenoid purpura,8 and amlodipine causing petechia.9 Rarely CCBs, like amlodipine, may also produce thrombocytopenia due to the development of amlodipine-dependent antibodies against platelets.10
The antianginal ejects of CCBs like diltiazem have been well established.
Bologa and co-investigators described the case of an 81-year-old female who became unresponsive after ingesting a potentially lethal amount of 5.6 grams of diltiazem in a suicide attempt.1 The patient was found unconscious in her home and rushed to the closest emergency department (ED) by emergency medical services, approximately one hour after ingestion.