(Chelating agents increase the urinary excretion of mercury  which includes thiol-based agents such as dimercaprol
(British anti-Lewisite (BAL)), penicillamine, unithiol (2,3-dimercaptopropane-1-sulfonate (DMPS)), and succimer (dimercaptosuccinic acid (DMSA)).
Early treatment employed two agents in tandem: calcium disodium ethylenediaminetetraacetic acid (EDTA), which is given intravenously, and dimercaprol
, which is injected into muscle tissue.
Researchers have now found that the drug, dimercaprol
, removes the toxin by attacking certain chemical features of acrolein, neutralizing it for safe removal by the body.
anti-Lewisite or dimercaprol
, and ethylenediaminetetraacetic acid.
Chelation agents include the oral agent succimer, the intramuscular agent dimercaprol
, and the intravenous agent CaEDTA [19-21].
Different chelating agents are used for particular metals although there are also pluripotent agents such as dimercaprol
, aminophenoxyethane-acetic acid (BAPTA), deferoxamine, Ca, [Na.sub.2]-EDTA, and D-penicillamine.
Edetate calcium disodium, dimercaprol
, and penicillamine are examples of commonly used chelation agents.
Copper chelators can be used in severe poisoning like dimercaprol
, D-penicillamine, British Anti-Lewisite (BAL), Ethylene Diamine Tetra Acetate (EDTA).
After the victim is decontaminated, BAL (Dimercaprol
) 4-5 mg/kg IM should be used.
Chelating agents such as edetate calcium disodium (EDTA), sodium 2, 3-dimercaptopropane sulfonate (DMPS), and dimercaprol
(BAL) have been reported (Table 1) [7-10].
There are six agents available to treat heavy metal (arsenic, gold, iron, lead, and mercury) intoxication: de-ferasirox (iron), deferoxamine (iron), dimercaprol
(arsenic, gold, lead, and mercury), edetate calcium disodium (lead), penicillamine (copper and mercury), and succimer (lead).
BAL (chemical name: dimercaprol
; 2,3-dimercaptopropanol) has been in use in the medical community for over 60 years, but since it causes serious side effects, it has now been.