In our previous study and in this study, we showed the effectiveness of transplanting rBM-MSC-DSCs to treat liver damage in an experimental animal model using dimethylnitrosamine
, which was consistent with previous study where carbon tetrachloride was used as a hepatotoxic agent .
(DMN) can induce hepatic sinusoidal endothelial injury and coagulation necrosis primarily in the central and periportal regions of the lobule [9,10].
Cigarette smoke contains a large number of substances which are recognized as carcinogens and mutagens including radioactive polonium, cadmium, benzopyrene, dimethylbenzanthracene, dimethylnitrosamine
, naphthalene and methnaphthalene.
The hepatotoxic effects of dimethylnitrosamine
in the rat.
The production of malignant primary hepatic tumours in the rat by feeding dimethylnitrosamine
. British Journal of Cancer 10:114-122.
Gene expression of type I, III and IV collagens in hepatic fibrosis induced by dimethylnitrosamine
in the rat.
 In that instance, the conclusion that the substance dimethylnitrosamine
, a carcinogen, was a human liver poison was based upon acute toxicity studies in rats, inhalation studies in dogs and mice, three sets of case studies in humans (two people each), pathology evidence, some DNA studies, and extensive circumstantial evidence, but no epidemiological studies.
In meat it forms carcinogenic nitrosamines, nitrosopyrrolidine and dimethylnitrosamine
, in the part per billion range (Rubin, 1977).
Additionally, some of the known carcinogens, such as benzo(a)pyrene, benzene, 2-naphthylamine, and dimethylnitrosamine
, are found in higher concentrations in sidestream smoke.(19) It is difficult to quantitate the exposure a child might have to environmental tobacco smoke because exposure depends on such things as how close in proximity the child is to the smoker, the frequency of smoking, the ventilation, and the type of cigarettes smoked.
(DMN) -- a known animal carcinogen -- is usually a potent mutagen in the Ames assay.
Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine
(DMN) is a semivolatile organic chemical produced as a byproduct of industrial processes and is also known to cause oxidative liver injury.