The geometry of the nitro groups in the dinitrobenzene
isomers has been explored before.
It is based on the conjugation reaction between GST and a substrate, CDNB (1-chloro 2, 4 dinitrobenzene
) in the presence of a cofactor: glutathione (GSH).
Lutz, "Vanilloid receptor (TRPV1)-deficient mice show increased susceptibility to dinitrobenzene
sulfonic acid induced colitis," Journal of Molecular Medicine, vol.
They are stableenough on voltammetric time scale for furthermanipulations.The objective of this research is to investigate the solvent and temperature dependence of first reduction process, to study the protonation of the first reduction products of dinitrobenzene
and to measure the heterogeneous electron transfer rate constants in HMPA solvent at different temperatures.The substrates are the three isomers of dinitrobenzenes
and the protonating agents are benzoic acid and salicylic acid.
In this case, colitis was induced by intracolonic administration of dinitrobenzene
sulfonic acid (DNBS), and mice were treated using a nonpsychotropic cannabinoid, known as cannabigerol .
Summary: A charge transfer complex is formed when antihistaminic drug react with m- dinitrobenzene
in basic medium.
Substrate Specific activity ([micro]mol/min/mg) GST1 GST2 Ethacrynic acid 24.91 [+ or -] 1.24 15.71 [+ or -] 2.53 Hydrogen peroxide 3.93 [+ or -] 0.38 nd 1-Chloro-2,4- 0.61 [+ or -] 0.122 0.542 [+ or -] 0.127 dinitrobenzene
trans, trans-Hepta-2, 0.11 [+ or -] 0.02 0.084 [+ or -] 0.01 4-dienal 1,2-Dichloro-4- Nd nd nitrobenzene p-nitrophenyl chloride Nd nd Sulfobromophthalein Nd nd trans-4-Phenyl-3- Nd nd butene-2-one Cumene hydroperoxide Nd nd Dichloromethane Nd nd nd: not detected.
Chemicals used in this study included anhydrous ethyl alcohol (EtOH; Commercial Alcohols) and dinitrobenzene
sulfonic acid (DNBS; MP Biomedicals).
The cyclopentenone prostaglandin 15-deoxy-delta(12,14)-PGJ2 attenuates the development of colon injury caused by dinitrobenzene
sulphonic acid in the rat.
Indeed, administration of infliximab restored the proper function of intestinal epithelium in CD patients [42,111] and prevented TNF-induced rearrangement of tight junction proteins (notably, occludin and zonula occludens-1) in dinitrobenzene
sulfonic acid- (DNBS-) induced colitis in mice .