(66) stated that the substitution of urea/thiourea on disubstituted
cinnamic-based hydroxamates (10) has a remarkable HDAC inhibitory effect and antiproliferative activity against tumor cell lines.
Also, being disubstituted
affords the ability to vary functional groups, offering greater control of polymer properties, according to the company.
The main sign of polymerization of monomers is the dramatic decrease of characteristic bands around 930-940 [cm.sup.-1], attributed to the out-of-plane deformation mode of the [alpha],[beta]- disubstituted
naphthalene ring, which indicates the opening of the oxazinic ring.
Hence, [WA-f.sub.50] and [WB-f.sub.75] had significantly different inhibition potency towards [alpha]-glucosidase activity despite having similar relative proportions unsubstituted (un-Xylp), monosubstituted, (2-Xylp or 3-Xylp), and disubstituted
xylose residues (2,3-Xylp) and degree of substitution but different ferulic acid content.
report the preparation of disubstituted
metal cholate hydrogel without any proper identification of products .
Some authors also have reported that the kinetic diffusion of the less-stable disubstituted
anthocyanins is faster than that of the trisubstituted ones.
99% of which is 2-6 disubstituted
piperidines, which have haemolytic, antibacterial, insecticidal and cytotoxic properties.
A recent comparative study of the antioxidant activity of several coumarins showed that 4-methylumbelliferone was completely inactive against liver toxicity induced by carbontetrachloride, whereas other C-6 and C-7 disubstituted
coumarins (esculetin and scoparone) significantly prevented oxidative stress induced by carbon-tetrachloride (Bilgin et al., 2011).
Recently, Prashanth and Revanasiddappa showed antimicrobial activity of glutamine linked 2, 3 disubstituted
quinazolinone derivatives as potent antimicrobial agent against both gram positive and gram negative bacteria .
Quadrelli, "HNO made-easy from photochemical cycloreversion of novel 3,5-heterocyclic disubstituted
1,2,4-oxadiazole-4-oxides," Tetrahedron, vol.
Use of Grignard reagents allows for the isolation of monosubstituted and disubstituted
products, whereas use of organolithium reagents allows for the isolation of only the disubstituted
The disappearance of the band at 1489 [cm.sup.-1] (disubstituted
benzene ring) (53) and the decrease of the peak at 753 [cm.sup.-1] (disubstituted
benzene ring) (53) were also noted.