At present, cerebroselective anticholinesterase drugs such as donepezil
, rivastigmine, and galantamine are mainstay therapy in AD.
Food and Drug Administration's approval of Corium's lead product candidate, Corplex Donepezil
, for the treatment of Alzheimer's disease, prior to March 31, 2020.
The affected drugs include: Azithromycin, Donepezil
, Haloperidol, Imipramine HCl, Isosorbide Dinitrate, Naratriptan, Ondansetron, Perphenazine, and Risperidone.
Several case reports showed that donepezil
could lead rarely to serious bradycardia needing pacemaker implantation and fatal ventricular arrhythmia (torsade de pointes (TdP)) [7,8].
In this study, we used donepezil
, a clinically important drug for treating Alzheimer's disease, with poor solubility  to develop a new type of nanostructured drug.
Cholinergic transmission is the main target for most of the current symptomatic therapies in neurodegenerative diseases, in the form of ACh esterase (AChE) inhibitors such as donepezil
. The pharmacological model based on scopolamine, which temporarily blocks muscarinic cholinergic receptors in the brain, is widely regarded as a standard model for investigating cognitive deficits and may be useful in the search for improved procognitive drugs.
29, 2017) that ranked the safety and effectiveness of four drugs currently used to treat Alzheimer's disease (AD) symptoms found that donepezil
(Aricept[R]) was most likely to improve cognition.
"Since odour identification tests have been shown to predict progression to Alzheimer's, we hypothesised that these tests would also allow us to discover which patients with MCI would be more likely to improve with donepezil
M2 EQUITYBITES-September 1, 2017-Zydus Cadila granted final FDA approval to market Donepezil
M2 PHARMA-September 1, 2017-Zydus Cadila granted final FDA approval to market Donepezil
is a drug used in the palliative treatment of AD.
Keywords: Alzheimer Disease, pharmacist, pharmacotherapy applications, caregivers, donepezil