dornase alfa

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Related to dornase alfa: Pulmozyme, cystic fibrosis

dor·nase al·fa

 (dôr′nās′ ăl′fə, -nāz′)
A genetically engineered enzyme used to hydrolyze the DNA in bronchial mucus, facilitating its expectoration, in the treatment of cystic fibrosis.

[(recombinant human) d(e)o(xy)r(ibo)n(ucle)ase (1) + alteration of alpha.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
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Currently, the company expects several biosimilars to be in clinical trials: Rituximab biosimilar (JHL1101) to treat rheumatoid arthritis and Non-Hodgkin's Lymphoma; Dornase alfa biosimilar (JHL1922) to manage symptoms of cystic fibrosis; as well as Trastuzumab biosimilar (JHL1188) to treat breast cancer.
NORDIC BUSINESS REPORT-December 21, 2017-JHL submits clinical trial application with the Dutch Healthcare Authority for proposed clinical trial of Dornase Alfa Biosimilar in the Netherlands
In contrast to control groups patients from the main group received the inhalation with surfactant emulsion 12 ml per kg, dornase alfa (25 mg, 2 times a day), almitrin (scheme).
He was on chronic antimicrobial therapy (inhaled colistin and oral azithromycin), as well as inhaled salbutamol, inhaled corticosteroids, dornase alfa, pancreatic enzymes, domperidone, omeprazole, PEG 3350, multivitamins including Vitamins D and K, insulin, ursodeoxycolic acid, furosemide and amilioride.
Acetylcysteine (Mucomyst) and guaifenesin are also helpful, but dornase alfa (Pulmozyme) is not indicated in non-CF patients and was actually harmful in one study.
A two-year randomized, placebo-controlled trial of dornase alfa In young patients with cystic fibrosis with mild lung function abnormalities.
The purpose of this article is to give a brief overview of how the drug dornase alfa (Pulmozyme (R), Genentech) affects CF, as well as how it is administered, its side effects and case studies.
A Crossover, Randomized, Controlled Trial of Dornase Alfa Before Versus After Physiotherapy in Cystic Fibrosis.
Dornase alfa (Pulmozyme) treatment reduced exacerbations in healthy cystic fibrosis patients who were 6-10 years old.
Pulmozyme(R) (dornase alfa) Inhalation Solution sales decreased 13 percent to $28.1 million in the second quarter of 2001 compared to $32.3 million in the second quarter of 2000.
Possibly the most innovative drug to win FDA approval last year was Genentech Inc.'s dornase alfa, which was what Hussar described as the first major advance for cystic fibrosis patients in 30 years.