Injury to dorsal root ganglia alters innervation of spinal cord dorsal horn
lamina involved in nociception.
Scientists in the Washington University laboratory found a receptor expressed in the spinal cord dorsal horn
and have shown that it functions as an itch-specific receptor.
Dexmedetomidine as an adjuvant to hyperbaric Bupivacaine in spinal anaesthesia prolongs the sensory block by inhibiting the release of C-fiber transmitters by hyper polarization of dorsal horn
post synaptic neurons.
The team focused on a set of neurons called Tac1 emanating from the so-called dorsal horn
, a cluster of nerves located at the lower end of the spinal cord that transmit signals between the brain and the rest of the body.
Rapamycin reduced mammalian target of rapamycin-sensitive complex 1 expression in the spinal dorsal horn
of mice treated with stavudine
Recent electrophysiological studies have demonstrated that, a stimulus which forms due to tissue damage stimulates afferent C fibres which in turn stimulates the dorsal horn
neurons, resulting in pain.16,17 Different surgical methods are likely to cause pain of varying severity.
In previous studies, effective therapy for NP focused on the primary sensory neurons and their influence on the activity of the spinal dorsal horn
After 3 days of intrathecal injection, lumbar (L1-5) spinal dorsal horn
of each rat was collected to assess the expression of TLR4, Myd88, and NF-[kappa]B by Western blotting as reported previously .
Ipsi-lateral spinal dorsal horn
tissue from L4-L6 were homogenized by radio immunoprecipitation assay (RIPA) lysis buffer (Western Biotechnology, Chongqing, China) at 100 mg tissue per mL and centrifuged.
Indeed, many studies have focused on neurons to understand the mechanism of neuropathic pain, which have suggested that neuropathic pain is a reflection of the aberrant excitability of the secondary sensory neurons in dorsal horn
evoked by peripheral sensory inputs and anatomical reorganization of pain pathways of the peripheral and central nervous systems.
(2) The central pathway: (1) information is transduced in the primary sensory neurons of the spinal DRG and then transmitted to the spinal dorsal horn
neurons (DHN), wherein nociceptive information is subject to primary central integration, followed by ascending transmission in the spinal cord through the spinothalamic tract, the spinoreticular tract, and the spinomesencephalic tract to the thalamus, the reticular formation, and the midbrain; further, the information is projected to the cerebral somatosensory cortex, the anterior cingulate cortex (ACC), and the insular cortex, resulting in visceral pain .