downregulation

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Related to down regulation: Upregulate

downregulation

(ˌdaʊnrɛɡjʊˈleɪʃən)
n
(Medicine) a decrease in sensitivity, through overexposure, to a drug or other chemical caused by a reduction in the number or density of receptors on cell surfaces
References in periodicals archive ?
The results by above mentioned formula showed down regulation of IL-18 in RA patients on DMARD therapy in this study population.
One of the earlier studies reported that down regulation of miR-100 showed no significant relationship with gender.19 Some other earlier researches have also reported no association of expression of miR-100 with age.20-22
Research teams at Medigene will work with scientists at RXi to explore potential advantages of transient down regulation of certain genes to prevent negative regulation of T cells expressing a recombinant TCR directed against a predefined tumor antigen.
RNAi-directed down regulation of OsBADH2 results in aroma (2-Acetyl-1-pyrroline) production in rice (Oryza sativa L.).
Lee et al., (2010) found non-significant down regulation of TNF-a in adipose tissues after treatment with nobiletin: flavonoid found in citrus fruits.
O ERP tem em consideracao esses dois modos e avalia em que medida as pessoas sao capazes de aumentar os efeitos de suas emocoes positivas (up regulation) ou reduzir os efeitos indesejaveis da expressao de suas emocoes negativas (down regulation) em situacoes em que se espera que essas emocoes sejam reguladas.
Trigonelline, a natural alkaloid found in fenugreek, is known to inhibit adipogenesis by its influences on the expression of peroxisome proliferator-activated receptor (PPAR[gamma]), which leads to subsequent down regulation of PPAR-[gamma] mediated pathway during adipogenesis.
The team found that STAT3 down regulation, via enhanced expression of PIAS3 or exposure to a peptide derived from PIAS3, inhibited cell growth and increased apoptosis in cancer cells.
These results were only partially confirmed by the results of the protein plasmas levels which found very significant up-regulation of IL-2 and down regulation of IL-6, borderline p-values for IL-8 and non-significant results for TNF-[alpha].
Treatment of adipocyte with of TG down regulates the peroxisome proliferatoractivated receptor (PPAR-[gamma]) and CCAAT element binding protein (C/EBP-[alpha]) mRNA expression, which leads to further down regulation of other gene such as adiponectin, adipogenin, leptin, resistin and adipocyte fatty acid binding protein (aP2) as compared with respective control cells on 5th and 10th day of differentiation.
MUC5AC down regulation was still significant in respiratory mucosa of the combined laryngeal and ventricular mucosa (P < 0.05) while statistical significance was lost in respiratory mucosa of posterior commissure mucosa.