downregulation


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Related to downregulation: Upregulation

downregulation

(ˌdaʊnrɛɡjʊˈleɪʃən)
n
(Medicine) a decrease in sensitivity, through overexposure, to a drug or other chemical caused by a reduction in the number or density of receptors on cell surfaces
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References in periodicals archive ?
PPAR[gamma] expression and role are already linked to trophoblast invasion [8, 9] and downregulation of RXR[alpha] is discussed as protection against apoptosis [4]; nothing is known about the role of the nuclear oxysterol receptor--the liver X receptor (LXR)--in miscarriage.
The 0.32 and 0.53 fold for the downregulation of the higher and lower doses of PDGF were found to be significantly the same (p [greater than or equal to] 0.05).
VPS4B, a member of the AAA (ATPases associated with diverse cellular activities) protein family, plays an important role in the lysosomal degradation pathway, which functions in ligand-induced membrane receptor downregulation. In lysosomal degradation, endocytosed receptors are sorted into multivesicular bodies (MVBs), which requires the sequential assembly of endosomal sorting complex required for transport I, II, and III (ESCRT-I, -II, and -III) on the endosomal membrane [1].
Comparing cardiac tissue of 12 patients with HC and 12 age-matched controls, researchers found decreased protein expression, or downregulation, in two sets of genes aligned sequentially along the genome.
The gene analysis undertaken in the current study found decreased protein expression, or downregulation, in two sets of genes aligned sequentially along the genome.
In addition, P-B and bLF combination inhibited cell proliferation more effectively by downregulation of PCNA, GST-n, NF-kB and mutant p53, and induced apoptosis by downregulation of Bcl-2 and upregulation of Bax, Fas and caspase-3 expression.
The treated cells exhibited reduced migration potential that could be explained due to downregulation of MMP-2 expression.
The results showed that changes induced in the gene expression in skin, by both intrinsic ageing and photoageing, are associated with down-regulation of epidermal differentiation and downregulation of wound healing, while photoageing is additionally associated with up-regulation of immune responses.
Collective results of WB and LC-MS strongly suggest upregulation of TolC and OmpA, and downregulation of Dps, 30S ribosomal protein S1, and EFTu in XDR strains.
They may be involved in tumour formation as oncogenes and there is general downregulation of miR in tumours.
Longer incubations of MM cells (24-48 hours) with ENMD-2076 free base elicited increased cell death with concomitant inhibition of Aurora A autophosphorylation, induction of cell cycle arrest, and downregulation of cyclins A and B1.