Overall, PSRs resulted in a WHO diagnosis in 80 of 85 cases (94%) compared with 54 (64%) for the hematopathology report alone, with increases observed in the cytopenia, MPN, plasma cell dyscrasia
, and lymphoma tracks.
Light-chain-mediated acute tubular interstitial nephritis: a poorly recognized pattern of renal disease in patients with plasma cell dyscrasia
. Arch Pathoi Lab Med 2006; 130: 165-169.
If associated with monoclonal plasma cell dyscrasia
, it is categorized as primary, and when it occurs as a complication of chronic inflammatory diseases, including rheumatoid arthritis, chronic osteomyelitis, or malignancies, it is categorized as secondary.
The exclusion criteria for this study were: refusal to receive blood products for any reason, a history of blood dyscrasia
or other clotting abnormality, anterior only surgical approach, or current use of an anticoagulant.
An SPE is appropriate, however, in an older patient with unexplained anemia, known low immunoglobulin levels, unexplained renal insufficiency or neuropathy, or osteopenia or osteoporosis inconsistent with the patient's age or gender--provided the patient doesn't have a coexisting plasma cell dyscrasia
or B-cell lymphoproliferative disorder, which would throw off the prognostic value of the test results, he continued.
Primary systemic amyloidosis (AL amyloidosis), which is usually associated with an underlying plasma cell dyscrasia
, involves the deposition of insoluble monoclonal immunoglobulin light chains in the skin, muscles, connective tissues, blood vessel walls, peripheral nerves, heart, kidneys, gastro-intestinal tract, and lungs (2).
"Epidermotropism refers to a state of abnormal colonization of the epidermis by leukocytes, which often reflects a clonal T-cell or monocyte dyscrasia
. Epidermotropism is a distinctive pattern of passive migration into epithelial structures that is not otherwise attributable to the normal function of innate and adaptive immunity," the researchers explained.
Her medical history was significant for extranodal marginal zone lymphoma, plasma cell dyscrasia
and amyloidosis diagnosed one year earlier following biopsy of a right cheek mass.
Also excluded were patients conforming to physical status classification IV (American Society of Anesthesiologists), those with a history of nasal fracture or previous nasal surgery, those with a history of sinusitis or nasal tumor, and those with underlying blood dyscrasia
Thus, myocardial scintigraphy can diagnose cardiac ATTR amyloidosis without histological confirmation as long as there is no plasma cell dyscrasia
However, the prevalence of the commonest inherited blood dyscrasia
among Asians, beta-thalassemia, has been evaluated among large populations in both China and India with similar prevalence of beta-thalassaemia status of around 3% [33, 34].