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n. disgerminoma, tumor maligno del ovario.
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TABLE 3 Common serum biomarkers for ovarian tumors Test Utility CEA Mucinous tumors CA 19-9 Pancreatic and other gastrointestinal cancers, rare ovarian tumors LDH Dysgerminomas AFP Liver cancer and gonadal tumors (ovarian yolk sac tumors) HE4 Epithelial ovarian cancer CA 125 Epithelial ovarian cancer Oval (a) Risk of ovarian malignancy ROMA Risk of ovarian malignancy Overa (a) Risk of ovarian malignancy (a) Multivariate index assay.
Dayan, "An immune reaction in man against seminomas, dysgerminomas, pinealomas, and the mediastinal tumours of similar histological appearance?," The Lancet, vol.
Dysgerminomas are the ovarian counterparts of testicular seminomas; they are occasionally bilateral, most common in adolescence and associated with elevated [beta]-HCG and LDH.
Although HHM-CIH is widely recognized and studied extensively in granulomatous diseases, increased expression and activity of 1-[alpha] hydroxylase resulting in overproduction of serum 1,25-dihydroxyvitamin D have also been demonstrated in in vivo studies investigating hypercalcemia associated with dysgerminomas [34] and B-cell lymphoma [35].
Dysgerminomas, gonadoblastomas, seminomas, and yolk sac carcinomas have been reported in ovotesticular DSD (8,9).
They show a high predisposition to ovarian cancer with the most frequent observed histotypes are gonadoblastomas and dysgerminomas, followed by Brenner tumors, malignant teratomas, and mixed endodermal sinus tumors.[sup][2],[5] The lifetime risk of gonadal tumors is in range of 15–35%.
Less often is may be due to ectopic PTH secretion (ovarian, lung, rhabdomyosarcoma, neuroectodermal tumor, thyroid papillary cancer) or ectopic production of 1, 25-dihydroxyvitamin D (calcitriol) in patients with lymphoma or ovarian dysgerminomas. Hypercalcemia results in AKI predominantly due to renal vasoconstriction and hypovolemia.
Dysgerminomas are the most common malignant germ cell neoplasms, accounting for about one-third of cases.
Regarding the malignant germ cell tumours which constituted 12 cases (19.67%), there were 6 dysgerminomas (9.84%), 3 cases (4.92%) of yolk sac tumours, 2 cases (3.28%) of Immature Teratomas and 1 case (1.64%) of mixed germ cell tumour (Table 4).
Dysgerminomas accounted for 44.4% of malignant germ cell tumours in this study, as opposed to 56% and 36.2 % in studies in the United States of America and Eastern India respectively (10).
Tumors of the ovaries include granulosa cell tumors, ovarian carcinomas, dysgerminomas, arrhenoblastomas, and teratomas.