DAPA-HF is the first outcomes trial with an SGLT2 inhibitor investigating the treatment of heart failure in patients with reduced ejection fraction
(HFrEF), with and without type-2 diabetes (T2D).
Farxiga is also being studied in patients with heart failure with preserved ejection fraction
(HFpEF) in the DELIVER and DETERMINE (HFrEF and HFpEF) trials.
Olgin, M.D., from the University of California in San Francisco, and colleagues randomized patients with acute myocardial infarction and an ejection fraction
of 35 percent or less to receive wearable cardioverter-defibrillator plus guideline-directed therapy (device group) or to receive only guideline-directed therapy (control group) (1,524 and 778 patients, respectively).
But in the treated animals the ejection fraction
had risen to 49.7 percent, about half-way back to normal.
The heart attacks reduced the hearts' left ventricular ejection fractions
That would be an upgrade from the current American College of Cardiology/American Heart Association guidelines on managing ventricular arrhythmias and preventing sudden cardiac death, issued in 2017, that classified WCDs as a class lib recommendations --"may be reasonable" --for post-MI patients with a reduced left ventricular ejection fraction
Low ejection fraction
(E.F) acts as a confounding factor.
In about half of all such people, the ejection fraction
of the heart is reduced.
Echocardiography showed depressed left ventricular function with an ejection fraction
A Left ventricular ejection fraction
(LVEF) is the percentage of blood pumped out of the heart's main pumping chamber during each contraction.
The ejection fraction
of LV was 65%, and a mobile, pedunculated heterogeneous mass originating from the interventricular septum and measuring 1.3x1.1 cm in diameter was observed on echocardiography (Figure 1).