for POL6014, a clinical stage selective inhibitor of human neutrophil elastase
with the potential to treat cystic fibrosis (CF) and other neutrophilic pulmonary diseases such as non-cystic fibrosis bronchiectasis (NCFB), alpha-1 antitrypsin deficiency (AATD) and primary ciliary dyskinesia (PCD).
POL6014 is a clinical stage selective inhibitor of human neutrophil elastase
with the potential to treat cystic fibrosis (CF), as well as other neutrophilic pulmonary diseases, such as non-cystic fibrosis bronchiectasis (NCFB), alpha-1 antitrypsin deficiency (AATD) and primary ciliary dyskinesia (PCD).
Trypsin, chymotrypsin, and elastase
activities in extracts of 5 mg total protein from larval guts of laboratory (NL, US), field (GTO), and Xentari-selected (USX) strains were compared.
UK-based biopharmaceutical company Mereo BioPharma Group plc (AIM: MPH) has reached an agreement with UK-based drugmaker AstraZeneca (NYSE: AZN) for an exclusive license, including an option to acquire, AZD9668, an oral inhibitor of neutrophil elastase
, the company said on Monday.
This financing complements the recent CARB-X grant of up to $8,9 million awarded to Antabio in July 2017 to support the company's Elastase
Inhibitor program (PEI) for the treatment of chronic Pseudomonas infections in Cystic Fibrosis patients.
These new zonulin ELISAs expand ALPCO's current gastrointestinal assay panel to investigate bile acids, calprotectin, alpha-1 antitrypsin, lysozyme, secretory IgA and pancreatic elastase
Since virulence factors like elastase
, protease, motility and biofilm formation in P.
Meantime, all the isolates (1-10) were evaluated for their anti-oxidative and inhibiting neutrophil elastase
activities by the bioassays in vitro.
released by microorganisms is an important virulence factor in several types of infections,  and the invasive effect of elastase
by Pseudomonas aeruginosa has been well documented.
screened 50 Korean plants to identify natural sources of elastase
and hyaluronidase inhibitors in 2010.
levels were adequate (>500 pg/g).
They also secrete several cytokines (TNF-[alpha], IL-8, IL-1[beta]) and extracellular matrix degrading enzymes such as elastase
and matrix metalloproteinases 2 and--9 (MMP-2 and 9).