This carbon in an isocyanate is an
electrophile that makes it highly reactive.
Importance of phase 2 gene regulation in protection against
electrophile and reactive oxygen toxicity and carcinogenesis.
Subsequent tuning of the reactivity and specificity of the
electrophile resulted in the discovery of a class of highly selective Btk inhibitors within the cysteine homolog family.
The possible explanations for these results included metal ions that may activate
electrophile and nucleophile binding, and release electrons to modulate PO activity (Stryer 1995), or divalent cations that may change the secondary structure of certain peptides of PO to influence PO activity (Feng et al.
This important regulatory element was also called the
electrophile responsive element (EpRE) (32).
The remaining 10% is metabolized via the cytochrome P-450 pathway to form N-acetyl-p-benzoquinone imine (NAPQI), a potent
electrophile, which is rapidly converted to a nontoxic moiety and excreted via conjugation with reduced glutathione.
The reaction phenol-formol corresponds to an
electrophile substitution in both acid and alkaline medium where the attack on the para position is supported by polar solvent and the acid conditions whereas the attack on the position ortho is supported by non-polar solvent in the alkaline medium [18].
Every compound targeted and prepared is new because of the difficulty inherent in traditional and other methods, and the synthesis represents another group of reactions where an anionic nucleophile is condensed with an anionic
electrophile.
The hydroxyl group of Tyr115 was found hydrogen-bonded to the 10-hydroxyl group of (9S,10S)-2, a fact suggesting that this residue could act as an
electrophile to stabilize the transition state for the addition of GSH to epoxides.
An acceptor is called an
electrophile and the reaction - electrophillic.
The constant interest of the membrane scientists for PSF is due to its excellent characteristics such as solubility in a large range of polar solvents, chemical stability, thermal resistance (150-170[degrees]C), wide pH value range application (2-12), resistance in oxidative medium (hypochlorite 5-7% and hydrogen peroxide 3-5%), high mechanical resistance of the PSF films (fracture, flexure, and torsion), and moderate reactivity that gives the possibility functionalization by aromatic
electrophile substitution or other reactions (8), (9).
In the Stille reaction, a stannylated alkene and an
electrophile, such as an aromatic halide or triflate are reacted in the presence of a palladium catalyst.
