Researchers sought to improve the efficacy and systemic anti-tumor response of OncoSec's clinical IT-pIL12-EP platform by modifying in vivo electroporation
conditions and enhancing plasmid-derived IL-12p70 expression.
Nowadays, Mirus Bio is the leading manufacturer of transfection reagents for chemical and/or electroporation
delivery of DNA, RNA, siRNA, miRNA, and other nucleic acids.
It features customizable electroporation
parameters for construct-specific optimization of expression, and it is the only in vivo electroporation
device enabled with TRACE Technology (Tissue-Based, Real-Time Adaptive Control Electroporation
(IRE) has emerged as a potential option for the management of unresectable pancreatic cancer.
i) pPG612-HCE-PgsA-vp2-rrnBT1T2, (ii) pPG612-HCE-T7g10-PgsA-vp2-rrnBT1T2 by electroporation
therapies use electrical pulses to improve drug delivery to cancer patients.
is a powerful technique in molecular biology.
A Northwestern University collaboration has developed a novel microlluidic device that allows for electroporation
of stem cells during differentiation, making it possible to deliver molecules during this pivotal time in a cell's life.
Cancer immunotherapies company OncoSec Medical (OTCQB:ONCS) said on Tuesday that the US Patent and Trademark Office (USPTO) has approved claims covering a method of treating cancerous tumors with plasmid-encoded IL-15 and electroporation
therapy to the tumor having a field strength of at least 700 V/cm.
Delay in electroporation
after mixing plasmid DNA and competent cells as in case of pre-electroporation
heat shock and use of PEG decreased the transformation efficiency.
OncoSec Medical had a busy July with clinical trials for various cancer treatment therapies, and the company finished out the month by achieving the ISO 13485 certification for electroporation
uses high-voltage pulses and can cause cell death rates of 30 to 60%.