of polymer nanofibers for tissue regeneration," Progress in Polymer Science, vol.
To this aim, polymeric nanofibers could be a good choice to mimic structure and function of natural ECM and, among the various techniques available for nanofiber fabrication, electrospinning
(ES) is very promising due to its simplicity, environmentally friendly nature, cost-effectiveness, and scalability .
Many kinds of biological scaffold-manufacturing technologies exist, with electrospinning
a commonly used method .
The integrated micro- and nanofibrous PCL scaffolds were fabricated using a combination of 3D-bioplotting and electrospinning
. The electrospun layers were cut into 14.5 mm diameter circles to match the size of the 3D scaffolds.
Fundamentals of Electrospinning
& Electrospun Nanofibers
This process, called electrospinning
, creates the scaffolds needed to attach to stem cells; however, large-scale production is not cost-effective.
(6,7) The melt spinning and electrospinning
of lignins have been studied to produce precursor fibers for carbonization.
has gained worldwide significance for fabricating micro and nano fibrous structures.
The most widely used method for fabricating nanofiber is electrospinning
, but there are intrinsic deficiencies when using it for mass production, and one theme of these papers is variations or alternatives that works better in various situations.
is an effective method for the production of polymeric fibers  with diameters ranging from tens of nanometers to microns.
is a simple and versatile technique that is capable of producing nanofibers with diameters ranging from 50 to 500 nm .
Currently, submicron fibres can be produced by various methods including fibrillation [1,2], splitting of bicomponent fibres , melt blowing , electrospinning
[5-7], centrifugal and force spinning, or combined processes [8-10].