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Related to elephantiasic: elephantiasis
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A diagnosis of elephantiasic PTM with hypothyroidism (post-treatment of radioactive iodine therapy for hyperthyreosis) and thyroid-associated ophthalmopathy was made.
Mild forms of pretibial myxoedema may regress spontaneously, but the rare, severe elephantiasic variant is often resistant to different therapeutic approaches including local and systemic corticosteroids, compression, plasmapheresis, and immunosuppressive agents (Felton et al 2003, Srebrnik et al 1992, Schwartz et al 2002).
Elephantiasic lesions occur almost always after chronic ulcers form, which leave intense fibrosis scarring and lead to lymph deterioration.