Krishna, Attempted Cycloaddition of N-Ethoxycarbonyl methylen enamine
to N Ethoxycarbonylazepine: Formation of 4, 4'-Bis(ethoxycarbonylamino)-diphenylmethane, J.C.S.
1H-NMR of ligand (PFA) revealed the presence of a single proton at 12.66 ppm due to the enamine
N-H group (Shi et al., 2005).
- Integrated drug discovery services provider Enamine
Ltd and Danish pharmaceutical company H.
Polymer materials that present hydrolysable chemical bonds along the polymer chain, such as in the amide, enamine
, ester, and urethane functional groups, present biodegradable characteristics and can also find agricultural applications.
We plan to accomplish this by exploiting the photochemistry of iminium ions in processes that synergistically combine enamine
chemistry with transition metal catalysis, Thus merging, For the first time, Tandem organo-metal catalysis with asymmetric photoreactions.
SAMDI Tech, a provider of label-free drug discovery solutions, has partnered with Enamine
, a supplier of drug-like screening compounds, to expand the number of molecules in their small molecule compound libraries.
developed an efficient, Pdcatalyzed Heck reaction in which the 2-triflate substituted aryl ketone series 74 was coupled and intramolecularly cyclized with enamine
75 at [C.sub.4f]-[C.sub.4]/[N.sub.2]-[C.sub.3] and isomerized to produce four examples of ring-fluorinated and fluoroarylated isoquinolines 76 .
Braz-Filho, "New enamine
derivatives of lapachol and biological activity," Anais da Academia Brasileira de Ciencias, vol.
Ligand Docking CoCoCo_ID VENDOR (*) Fitness Score (kcal/mol) LJH68 -12.282 - - (Native Ligand) 5777208 -13.183 5777208 NCI 1.654556 1356444 -12.714 1356444 CBN 1.553880 5919607 -12.426 5919607 PRN 2.114975 1906060 -12.049 1906060 CHD 1.495216 2231818 -11.763 2231818 CHD, PRN 1.765809 6739988 -11.693 6739988 PRN 2.137922 810148 -11.680 810148 CBE, PRN 2.073499 5923852 -11.654 5923852 PRN 2.100553 1963198 -11.420 1963198 CHD 1.544532 4501898 -11.018 4501898 ENM 1.548856 1384260 -11.011 1384260 CBN 1.763145 416963 -10.834 416963 ANG, CHD 1.909153 (*) NCI: National Cancer Institute; CBE/CBN: ChemBridge; PRN: Princeton Biomolecular Research Inc; CHD: ChemDiv; ENM: Enamine
(19.) Lansdale, ACL, Maple Glen, DAB, North Wales, WTB, "Functionalization of Polymers Via Enamine
of Acetoacetate." US Patent 5,494,975, 1996
Alexakis, "Chiral amines as organocatalysts for asymmetric conjugate addition to nitroolefins and vinyl sulfones via enamine
activation," Chemical Communications, no.
Weingarten, "A versatile new enamine
synthesis," Journal of Organic Chemistry, vol.