Lee, "Liquid chromatographic enantiomer
separation of 1-naphthylamides of chiral acids using several amylose- and cellulose-derived chiral stationary phases," Archives of Pharmacal Research, vol.
For chiral drugs, especially those with different activities and effects associated with each enantiomer
, stereoselectivity in protein binding is an important consideration.
The Food and Drug Administration has granted Janssen Pharmaceuticals "fast track" and "breakthrough therapy" status for intranasal esketamine, the S(+) enantiomer
of ketamine, which is now in phase III clinical trials for treatment-resistant depression as well as for depression with suicidal thoughts.
In the cases of trogodermal (2'), exo-brevicomin (3) and frontalin (4), only a single enantiomer
of the pheromone was highly bioactive.
In particular, the rhizopines produced allowed us to confirm which was the naturally active enantiomer
('hand') of a key bioactive compound.'
The development of robust and widely applicable methods that form single enantiomer
products is a major contemporary research goal.
The patent includes claims that cover compositions of the immunologically active enantiomer
of the cationic lipid R-1,2-dioleoyl-3-trimethyl-ammonium-propane or its racemic mixture with Granulocyte-macrophage colony-stimulating factor to reduce the population of myeloid derived suppressor cells within the tumor microenvironment.
The PLLA and PDLA enantiomer
generate polar interactions with sc-DME to dissolve efficiently because DME has a dipole moment of 1.3 D .
In addition to the concentration values, authors [7, 8, 14] often present as results the ratio between the total area of the chromatographic peak and the specific area of the diastereomer or enantiomer
. The result of the calculation is called the diastereomeric factor (DF) or the enantiomeric factor (EF) .
Levobupivacaine is the pure S (-) enantiomer
of racemic bupivacaine.
Ethyl acetate, acetic acid, methanol, 2-propanol, ammonium hydroxide, dichloromethane, 0.1 M solution of (S)-(-)-N-(trifluoroacetyl)pyrrolidine-2-carbonyl chloride (L-TPC) with an enantiomer
excess (ee) of 97% (according to the supplier's specification) in methylene chloride, anhydrous sodium sulfate, and sodium phosphate were obtained from Sigma-Aldrich Chemicals (St.
- US-based autoimmune disease therapies developer ImmunoMolecular Therapeutics (IM Therapeutics) has been issued US Patent 9,629,848 covering the use of methyldopa (MDOPA) and other small molecular entities in immunotherapy for type 1 diabetes and US Patent 9,820,957 covering the use of the D enantiomer
of methyldopa (D-MDOPA) for T1D and celiac disease, the company said.