US-based autoimmune disease therapies developer ImmunoMolecular Therapeutics (IM Therapeutics) has been issued US Patent 9,629,848 covering the use of methyldopa (MDOPA) and other small molecular entities in immunotherapy for type 1 diabetes and US Patent 9,820,957 covering the use of the D enantiomer
of methyldopa (D-MDOPA) for T1D and celiac disease, the company said.
Levobupivacaine contains a single enantiomer
of bupivacaine hydrochloride belonging to the family of n-alkyl substituted pipecoloxylidide.
Chemists long ago discovered that when a drug has effects in the very chiral environment that is the human body, it is often only one enantiomer
of the drug that is doing the work, while the other is inert.
While a somewhat unusual case, the SCC confirmed that the selection of one enantiomer
from a known racemate, with the disclosure that the selected enantiomer
had better activity, constituted a valid selection.
The S- enantiomer
produces anaesthesia of longer duration than the racemate-form1.
14, 15) We used (-)-Sp as the chiral ligand for the enantiomer
-selective polymerization of racemic 1-phenylethyl methacrylate in 1977, and found that a very high enantiomer
selection takes place when combined with Grignard reagents.
The difference can be so great that one of the enantiomers
shows the desirable medical properties while another enantiomer
is known as a highly toxic component for the biological environment.
The optical resolution of racemates has been essential in the perfume production pharmaceutical industry food preparation and so forth due to the harmful effect of one of the enantiomer
of racemate mixture.
For example, carvone is a chiral terpenoid where the R enantiomer
smells like spearmint while the S enantiomer
has the distinct odor of caraway seed.
Gonzaolez, "Development of a new method for the enantiomer
specific determination of HBCD using an ion trap mass spectrometer," Analytica Chimica Acta, vol.
The S(+) enantiomer
is associated with prostaglandin inhibition and toxicity and the R(-) enantiomer
is linked with analgesic action and protection of gastrointestinal tract.
For this purpose we have developed a special, highly efficient catalyst system which ensures that mainly just a certain enantiomer
is synthesized from the citral.