Despite the demonstrated importance of chiral drugs, the detailed physics underlying the biomolecular interactions responsible for their enantiomeric
selectivity often remain obscure.
Depending on the details of the reaction to be enhanced, a chemist can design the catalyst to speed up many kinds of chemical processes, creating the desired enantiomeric
Dunlap is a codeveloper of selenium-based reagents that allow chemists to determine enantiomeric
abundances for certain classes of molecules using NMR.
The title will cover new material including the use of enzymes for the synthesis and resolution of enantiomeric
compounds as well, as their use in drug discovery; how stereochemistry impacts on decisions taken during the ADMET (absorption, distribution, metabolism, excretion, toxicity) stage of drug discovery; issues faced during the final stages of the drug development process; the impact of ICH (International Conference on Harmonisation) on the use of single isomer drugs; racemic switches; and legal perspectives looking at IP and patent issues surrounding chiral switches and marketing single enantiomer switches.
l] firstly reported the stereocomplex formation between enantiomeric
poly(L-lactide) (PLLA) and poly(Dlactide) (PDLA).
Li, Comparative study on enantiomeric
excess of main akannin/shikonin derivatives isolated from the roots of three endemic Boraginaceae plants in China, Biomed.
In 1973 when I began the synthesis of (S)-2, almost nothing was known about the absolute configuration of chiral and non-racemic pheromones, and it was not even clear whether enantiomeric
composition would play a role at all in pheromonal communications.
We will examine the conformational space of several chiral odorants to explore the possible link between conformational flexibility and enantiomeric
discrimination of odorants.
excesses (ee) were determined by chiral HPLC with chiral column (OJ-H, OD-H or 0J).
Hexabromocyclododecane in human breast milk: levels and enantiomeric
Quantitative determination of enantiomeric
Currently, synthetic routes to synthesize the unnatural analogs of the & aplha;-methyl amino acids easily, inexpensively, and with sufficient enantiomeric
yields does not exist.