grafts (tibia or iliac crest) show more reabsorption than bones of an intramembrane origin, in which even the final volume tends to increase.
Then Retting and Buer reported that SMAD5 is required for endochondral bone
formation (Retting et al.
2005); previous study has shown that choline kinase was required for normal endochondral bone
formation (Li et al.
sup],, These problems can in turn cause new trauma responses of the fracture area, extend the inflammation period, stimulate large amounts of inflammation, stimulate blood vessel reactions, increase the local blood supply, induce vascularization, enhance intramembranous ossification and endochondral bone
, and promote fracture healing.
sup] These nodules can ossify by endochondral bone
formation and attach to the synovium by a thin vascular pedicle.
Angiogenesis, the process of generating new blood vessels from pre-existing blood vessels, is involved in endochondral bone
formation and bone fracture repair.
Reddi, "Influence of estrogen and progesterone on matrix-induced endochondral bone
formation," Calcified Tissue International, vol.
Previous research which focused on the study of development of the symphysis and condyle (29) found that the cartilage of the mandibular condyle allows the endochondral bone
to grow, thus exerting an adaptive role in the growing site, being this growth determined by genetic and epigenetic factors (30); but it can also be influenced by cytokines, hormones, vitamins and mechanical stimuli (31,32).
Osteopoikilosis (OPK) is a benign rare disorder of the endochondral bone
, characterized by small multiple osteocondensation lesions, maximum 10 mm, usually found in the long bones of the limbs, hand, foot, pelvis and spine.