Tamblyn et al., "The Epstein-Barr virusencoded BILF1 protein modulates immune recognition of endogenously processed antigen by targeting major histocompatibility complex class I molecules trafficking on both the exocytic and endocytic
pathways," Journal of Virology, vol.
Ruponen, "Genetic blockage of endocytic
pathways reveals differences in the intracellular processing of nonviral gene delivery systems," Journal of Controlled Release, vol.
The formation of an intermediary phagosome is dynamic process involving fusion of endocytic
vesicles and fission of secretory vesicles, resulting in remodeling of the membrane and progressive acidification of the phagosome .
In contrast to PI3K gene knockout models, these mouse lines allow us to specifically address kinase-dependent functions and hence are an ideal model to evaluate the potential of class II PI3Ks as drug targets.The class II PI3K-C2a (C2a) is involved in endo- and exocytosis as well as endocytic
recycling, whereas PI3K-C2 (C2) has been implicated in cell migration.
By contrast, AP-2 adaptin binds to CI-MPR on cell surfaces and forms endocytic
vesicles in combination with other different coat proteins.
The mechanism through which MT-II exerts its protective effect when exogenously administered has not been elucidated; however, there is evidence that this protein can be carried by the megalin receptor, a known multiligand, endocytic
receptor with significant physiological function.
Yang et al., "Distinct endocytic
pathways control the rate and extent of synaptic vesicle protein recycling," Neuron, vol.
Exosomes are small, secreted membrane vesicles (30-100 nm in diameter) of endocytic
origin, produced by many different cell types that are formed by the fusion of multivesicular endosomes with the plasma membrane.
Several in vitro studies have shown QDs to be incorporated via endocytic
mechanisms by a variety of cell types.
A likely explanation for this finding is that DBP and DBP-bound vitamin D metabolites filtered through the glomerulus are reabsorbed by the endocytic
receptor megalin into cells in the proximal tubules (25).
Studies on eukaryotic microbial parasites show that, in the vast majority of cases, the nascent vacuole that contains the microbe fails to continue through the complete endocytic
pathway that culminates in acidification of the vacuole and fusion with lysosomes.
Exosomal uptake can take place by endocytosis; however, the endocytic
pathway has multiple mechanisms for uptake.