In this Update, we discuss data from a review that provides quantitative information on the likelihood of finding endometrial cancer
among women with postmenopausal bleeding (PMB).
The presence of postmenopausal bleeding as prognostic parameter in patients with endometrial cancer
: A retrospective multi-centre study.
Screening all women who experience bleeding after menopause for endometrial cancer
could potentially find as many as 90% of these cancers, which are highly curable if found early.
is the most common extracolonic cancer in Lynch syndrome that accounts for 2 to 5 % of all endometrial cancers
The surgical specimens of all newly diagnosed patients with endometrial cancer
should undergo IHC staining for the mismatch repair proteins MLH1, MSH2, MSH6, and PMS2.
, or cancer of the uterus, is the most common of the gynecologic cancers in the U.S.
Data from the study showed that Apristor, a novel extended release formulation of onapristone, was well tolerated and provided a clinical benefit in patients with previously treated recurrent or metastatic progesterone receptor-driven breast, ovarian and endometrial cancers
The researchers found that the pooled prevalence of PMB among women with endometrial cancer
was 91 percent, irrespective of tumor stage.
In addition to ongoing clinical studies of the combination, the companies will jointly initiate new clinical studies evaluating the combination to support 11 potential indications in six types of cancer (bladder cancer, endometrial cancer
, head and neck cancer, hepatocellular carcinoma, melanoma and non-small cell lung cancer), as well as a basket trial targeting six additional cancer types.
Even after adjustment for potentially confounding factors, the cohort of 2,648 endometrial cancer
survivors in this retrospective study had a "high burden" of cardiovascular events compared with 10,503 age-matched women, according to the investigators.
survivors were 47% more likely to be diagnosed with a disease of the heart between one of five years after cancer diagnosis and 33% more likely to be diagnosed with a disease of the heart between five to ten years after the initial cancer diagnosis.
Methods: One hundred and fifty patients with endometrial cancer
who were admitted to Binzhou People's Hospital, Shandong, China, between June 2013 and July 2014, were enrolled and set as an endometrial cancer
group; another one hundred patients with benign uterine diseases and one hundred healthy females were also enrolled.