Endometrial carcinomas can be further classified by histology as endometrioid adenocarcinoma
, serous adenocarcinoma, clear cell adenocarcinoma, mixed cell carcinoma, mucinous adenocarcinoma, metaplastic carcinoma (carcinosarcoma), squamous cell carcinoma, transitional cell carcinoma, small cell carcinoma, undifferentiated carcinoma, and others (4).
Briefly, features that favored endometrioid adenocarcinoma
morphologically included a background of hyperplasia, squamous and/or mucinous metaplasia, sharp luminal borders, a cribriform growth pattern, and, usually, lower-grade nuclei.
; FIGO (International Federation of Gynecology and Obstetrics) grade three endometrioid adenocarcinoma
Tissue histology was that of a high grade left ovarian serous / endometrioid adenocarcinoma
with no surface involvement.
Seven cases of malignant transformation of endometriosis of the urinary bladder have been published: three involved endometrioid adenocarcinoma
, one involved endometrial stromal sarcoma, and three involved clear cell carcinoma (1, 2, 4-7).
aimed to investigate p27 expression in the normal endometrium and endometrioid adenocarcinoma
of the uterine corpus and the correlation of its expression with cell proliferation and clinicopathological parameters.
was the most common histology.
Moore and his associates reported that serum HE4 levels also were high when patients with endometrioid adenocarcinoma
of the uterus had myometrial depth of invasion of greater than 50%.
Its prevalence is believed to be higher than had been previously thought, as many cases of UEC were either reported as endometrioid adenocarcinoma
FIGO (International Federation of Gynecology and Obstetrics) grade (3,6-8) or as high-grade sarcomas and carcinosarcomas.
1,2) Endometrioid adenocarcinoma
also typically exhibits glandular, papillary, and solid patterns, but variant patterns in endometrioid tumors have been described.
The most frequently encountered nonteratomatous primary tumors showing squamous differentiation are ovarian endometrioid adenocarcinoma
of the ovary and the Brenner tumor.
Both conditions may display associated squamous differentiation, in the form of central squamous morules in endometrioid adenocarcinoma
and immature squamous metaplasia in microglandular hyperplasia.