However, the connective tissue coverings namely the endoneurium
, perineurium and epineurium remain intact to guide and redirect the growth of axonal buds during the regeneration process.
A peripheral nerve is composed of axon, myelin, endoneurium
, fascicle, perineurium and epineurium.
The present study demonstrated that this marker was clearly seen around the capillaries in the endoneurium
of sciatic nerve.
More over exercise training has been proved as an effective tool for the improvement of vascular functions in patients of type 2 diabetes mellitus,normal vascular functions established due to adequate amount of physical activity will ultimately help maintaining endoneurium
blood flow there would brighter chances to prevent diabetic peripheral neuropathy in patients4 which shows high prevalence in diabetic patients of Pakistan.5 Early diagnosis and early management of type 2 diabetes mellitus with diet and physical activity will ultimately help doctors to put patients on reduced dosage of medications especially those who are already suffering from liver and kidney disease and can develop lactic acidosis a fatal condition due to diabetic medications i.e.
Each fascicle is enveloped by thloped by the endoneurium
, a layer of lax connective tissue.
Early stages are characterized by expansion of the endoneurium
by myxoid ground substance.
Besides the hematogenous macrophages invading the myelin or axons, there are a considerable number of resident macrophages within the endoneurium
of peripheral nerve.
NF-[kappa]B activation, which is involved in the pathogenesis of diabetic complications, especially DPN , has been identified in the endoneurium
, epineurial vessels and perineurium in sural nerve biopsies of overt diabetic subjects .
Delayed clinical improvement prompted a biopsy and histopathological examination of the medial antebrachial nerve of the left forearm during the 7th week of illness which demonstrated an inflammatory neuropathy characterized by inflammatory changes in the endoneurium
, perineurium, and epineurium.
A thickening of the walls of the microvessels in the endoneurium
and perineurium has been demonstrated in a few case reports of patients who had nerve segment resection.
Nerve tissue is damaged but the preserved architecture of the endoneurium
may enable regeneration (6).
Several weeks after exposure to OPs, we found angiodistonic disturbances, new or opening of pre-existed arteriovenous anastomoses, dilated and distonic venules within the endoneurium
of sciatic nerve, and mesenterium of small intestine (Figure 2).