Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.


 (ĕn′dō-no͞o′klē-ās′, -āz′, -nyo͞o′-)
Any of a group of enzymes that catalyze the hydrolysis of bonds between nucleotides in the interior of a DNA or RNA molecule.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Biochemistry) an enzyme that is responsible for scission of a nucleic acid chain, the action of which is not confined to the terminal nucleotide. Compare exonuclease
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˌɛn doʊˈnu kliˌeɪs, -ˌeɪz, -ˈnyu-)

any of a group of enzymes that degrade DNA or RNA molecules by breaking linkages within the polynucleotide chains.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.endonuclease - a nuclease that cleaves nucleic acids at interior bonds and so produces fragments of various sizes
nuclease - general term for enzymes that catalyze the hydrolysis of nucleic acid by cleaving chains of nucleotides into smaller units
restriction endonuclease, restriction enzyme, restriction nuclease - any of the enzymes that cut nucleic acid at specific restriction sites and produce restriction fragments; obtained from bacteria (where they cripple viral invaders); used in recombinant DNA technology
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Unlike other currently available antiviral treatments, Xofluza is the first in a new class of antivirals designed to inhibit the cap-dependent endonuclease protein, which is essential for viral replication.
In the CRISPRi system, scientists co-express a catalytically dead Cas9 (dCas9) lacking endonuclease activity with the gRNA.
Xofluza has a novel mechanism of action that inhibits cap-dependent endonuclease, an essential enzyme for viral replication.
In order to produce sticky or complementary ends, insert DNA and vector are separately cut with the same restriction endonuclease enzymes.
5, 2018 (HealthDay News) -- The selective inhibitor of influenza cap-dependent endonuclease, baloxavir marboxil, is superior to placebo for alleviating influenza symptoms, according to a study published in the Sept.
Lubna noted that proteomics analysis revealed that the induction of apoptosis by metformin in breast adenocarcinoma cell line was via the intrinsic caspase independent signalling pathway through upregulation of Endonuclease G (ENDO-G) and Apoptosis-inducing factor (AIF).
Both DNA and RNA are generally linear tetrapolymers, and nuclease enzymes known as exonucleases hydrolytically cleave these types of polymers at their ends (e.g., Phosphodiesterase I), while endonuclease enzymes cleave the polymer chain at internal locations (e.g., DNase I, EcoRI).
Cas9, a programmable RNA guided endonuclease, is the most widely used endonuclease for genomic editing among the several Cas proteins available.
Cas9 endonuclease form complex with both RNA components.
The assay mixture consisted of 0.5 [micro]mol/L PCR primers, 100 nmol/L upstream probe (U-probe), 50 nmol/L downstream probe (D-probe), 200 nmol/L hairpin probe, 3 nmol/L silica-modified GNPs, 62.5 [micro]mol/L dNTPs, 0.25 U GoTaq DNA polymerase (Promega), 80 ng of Aju flap endonuclease [in buffer containing 10 mmol/L Tris-HCl (pH 8.5), 30 mmol/L NaCl, 7.5 mmol/L Mg[Cl.sub.2], 0.05% Tween-20, 0.05% Nonidet P-40, and 1% PEG 8000], and the templates of interest.
Also, a DNA repair enzyme derived from bacteria, T4 endonuclease V showed promise in an older study of 30 patients with xeroderma pigmentosum (Lancet.