Then in 1997 they developed an in vitro test, the endopeptidase
method (Ekong et al., 1997).
The combination of sacubitril and valsartan inhibits neprilysin (a neutral endopeptidase
) and blocks angiotensin II type-1 receptors.
Legumain (LGMN) also known as asparaginyl endopeptidase
(AEP) is implicated in various cancer such as prostrate, breast, colon, lung, ovarian, central nervous system (CNS) related cancers, melanoma and lymphoma (1).
It reduced pulmonary inflammation by decreasing prolyl endopeptidase
activity and acetyl-proline-glycine-proline. In a therapeutic protocol, the influence of using PDE-4 inhibitors to reduce lung fibrosis was almost same to nintedanib and pirfenidone.
It is also known as neprilysin, common acute lymphoblastic leukemia/lymphoma antigen (CALLA) and neutral endopeptidase
For dermatophytes, including those causing tinea corporis, amino acids are regarded as a source for growth.16 Under in vivo condition, dermatophytes secret several types of endopeptidase
and exopeptidase in the presence of keratin as a sole nitrogen source.17 These enzymes digest proteins into peptides and free amino acids to be used as nutrients by fungi.18 One of these proteins is filaggrin that acts in assembling of keratin bundles.
The Inhibitory Effects of Anti-Oxidants on Ultraviolet-Induced Up-Regulation of the Wrinkling-Inducing Enzyme Neutral Endopeptidase
in Human Fibroblasts.
 Non-infectious cases of CNS have been reported in association with maternal systemic lupus erythematosus and neonatal alloimmunisation against neonatal endopeptidase
present on podocytes.
Partial downregulated DEGs were enriched in the GO categories 'serine-type endopeptidase
inhibitor activity' (n = 14, p = 3.21x[10.sup.-8]) and 'negative regulation of serine-type endopeptidase
activity' (n = 5, p = 3.42x[10.sup.-3]).
Currently, the term "peptidase" is also used equivalently with "protease" and "proteinase." Peptidase was restricted to the enzymes included in subsubclasses EC 3.4.11-19, the exopeptidases in the Enzyme Nomenclature (1984), while the term "proteinases" was previously used for the enzymes included in subsubclasses EC 3.4.21-99 having the same meaning as "endopeptidase
." However, the terms "protease" and "proteinase" are still preferred by many scientists .
cleaves AaAaAeAA[+ or -]-synuclein and mediates pathologic activities in Parkinson's (http://www.medicaldaily.com/link-between-parkinsons-and-alzheimers-diseases-may-lead-new-parkinsons-419730 disease . Nature Structural and Molecular Biology. 2017