endopeptidase


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Related to endopeptidase: neutral endopeptidase

en·do·pep·ti·dase

 (ĕn′dō-pĕp′tĭ-dās′, -dāz′)
n.
Any of a large group of enzymes that catalyze the hydrolysis of peptide bonds in the interior of a polypeptide chain or protein molecule.

endopeptidase

(ˌɛndəʊˈpɛptɪˌdeɪz)
n
(Biochemistry) any proteolytic enzyme, such as pepsin, that splits a protein into smaller peptide fragments. Also called: proteinase Compare exopeptidase
Translations
endoprotéase
References in periodicals archive ?
Then in 1997 they developed an in vitro test, the endopeptidase method (Ekong et al., 1997).
The combination of sacubitril and valsartan inhibits neprilysin (a neutral endopeptidase) and blocks angiotensin II type-1 receptors.
Legumain (LGMN) also known as asparaginyl endopeptidase (AEP) is implicated in various cancer such as prostrate, breast, colon, lung, ovarian, central nervous system (CNS) related cancers, melanoma and lymphoma (1).
It reduced pulmonary inflammation by decreasing prolyl endopeptidase activity and acetyl-proline-glycine-proline.[25] In a therapeutic protocol, the influence of using PDE-4 inhibitors to reduce lung fibrosis was almost same to nintedanib and pirfenidone.
It is also known as neprilysin, common acute lymphoblastic leukemia/lymphoma antigen (CALLA) and neutral endopeptidase (NEP).
For dermatophytes, including those causing tinea corporis, amino acids are regarded as a source for growth.16 Under in vivo condition, dermatophytes secret several types of endopeptidase and exopeptidase in the presence of keratin as a sole nitrogen source.17 These enzymes digest proteins into peptides and free amino acids to be used as nutrients by fungi.18 One of these proteins is filaggrin that acts in assembling of keratin bundles.
The Inhibitory Effects of Anti-Oxidants on Ultraviolet-Induced Up-Regulation of the Wrinkling-Inducing Enzyme Neutral Endopeptidase in Human Fibroblasts.
[9] Non-infectious cases of CNS have been reported in association with maternal systemic lupus erythematosus and neonatal alloimmunisation against neonatal endopeptidase present on podocytes.
Partial downregulated DEGs were enriched in the GO categories 'serine-type endopeptidase inhibitor activity' (n = 14, p = 3.21x[10.sup.-8]) and 'negative regulation of serine-type endopeptidase activity' (n = 5, p = 3.42x[10.sup.-3]).
Currently, the term "peptidase" is also used equivalently with "protease" and "proteinase." Peptidase was restricted to the enzymes included in subsubclasses EC 3.4.11-19, the exopeptidases in the Enzyme Nomenclature (1984), while the term "proteinases" was previously used for the enzymes included in subsubclasses EC 3.4.21-99 having the same meaning as "endopeptidase." However, the terms "protease" and "proteinase" are still preferred by many scientists [3].
Asparagine endopeptidase cleaves AaAaAeAA[+ or -]-synuclein and mediates pathologic activities in Parkinson's (http://www.medicaldaily.com/link-between-parkinsons-and-alzheimers-diseases-may-lead-new-parkinsons-419730 disease . Nature Structural and Molecular Biology. 2017