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A naturally occurring antiangiogenic protein that inhibits the proliferation of endothelial cells and is under investigation for use in the treatment of diseases associated with abnormal blood vessel growth, including certain cancerous tumors.

[endo(thelial) + -stat + -in.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
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M2 PRESSWIRE-August 23, 2019-: China Recombinant Human Endostatin Investigation Market Report, 2019-2023
This award will support the development for ovarian cancer an anti-HER2 antibody fusion candidate that contains a highly anti-angiogenic dimeric mutant endostatin as its fusion partner.
The most frequently studied stimulants of angiogenesis in bladder cancer are VEGF, thymidine phosphorylase, matrix metalloproteinases (basic fibroblast growth factor b-FGF), carbonic anhydrase 9, and cyclo-oxygenase 2, while the most studied suppressors include angiostatin, endostatin, p53 and thrombospondin-1 (11).
Expression of proinflammatory factors, proangiogenic factors and endostatin in patients with heart failure and different grades of collateral circulation development.
This complex process is controlled via an appropriate balance between angiogenic factors such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and angiogenin (1) and antiangiogenic factors such as thrombospondin-1, endostatin, and angiostatin.
Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma.
Endostatin stimulates proliferation and migration of adult rat cardiac fibroblasts through PI3K/Akt pathway.
Endostatin prevents dietary-induced obesity by inhibiting adipogenesis and angiogenesis.
Among these factors it can be pointed to angiostatin, endostatin, vasostatin, certain interleukins (ILs) such as IL-4 and IL-12 and also alpha, beta, and gamma interferons (IFNs).
Clinical significance of vascular endothelial growth factor and endostatin levels in the differential diagnosis of malignant and benign ascites.
The antiangiogenic effects of AM are a result of the expression of tissue metalloproteinase and endostatin inhibitors, as well as proteins which stimulate corneal epithelial proliferation and suppress vascular endothelial cell growth.
Cartilage is a nonvascular tissue and eludes vascularization by secreting antiangiogenic compounds (thrombospondin-1, chondromodulin-1, and SPARC (secreted protein acidic and rich in cysteine)), collagen type II derived N-terminal propeptide (PIIBNP), and the type XVIII derived endostatin [32].